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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sun, Y. S. He, J. M. Pu, Y. D. Wu, Y. J. Chen, L. P. Qin, R. Zhang, Q. J. Zheng, W. W. |
| Description | Country affiliation: China Author Affiliation: He JM ( Department of General Surgery, Hospital of the Chinese People's Liberation Army, Beijing, China wcg_xmc@163.com.); Pu YD ( Department of General Surgery, Hospital of the Chinese People's Liberation Army, Beijing, China.); Wu YJ ( Department of General Surgery, Hospital of the Chinese People's Liberation Army, Beijing, China.); Qin R ( Department of General Surgery, Hospital of the Chinese People's Liberation Army, Beijing, China.); Zhang QJ ( Department of General Surgery, Hospital of the Chinese People's Liberation Army, Beijing, China.); Sun YS ( Department of General Surgery, Hospital of the Chinese People's Liberation Army, Beijing, China.); Zheng WW ( General Surgery Department, Xinxiang Medical College, Weihui, China.); Chen LP ( General Surgery Department, Xinxiang Medical College, Weihui, China.) |
| Abstract | We investigated the association between dietary intake of folate, vitamin B6, and the 5,10-methylenetetrahydrofolate reductase (MTHFR) genotype with breast cancer. A matched case-control study was conducted, and 413 patients with newly diagnosed and histologically confirmed breast cancer and 436 controls were recruited. Folate intake, vitamin B6, and vitamin B12 levels were calculated, and the MTHFR C677T and A1298C and MTR A2756G polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism. Breast cancer cases were generally older, older at first live birth, and younger at menarche, had a higher body mass index, were smokers, had higher energy intake, and more first-degree relatives with breast cancer as well as more live births compared to controls. With respect to energy intake, we found that higher energy intake were more likely to increase the risk of breast cancer. The MTHFR 667TT genotype was associated with a moderately increased risk of breast cancer when compared with the CC genotype, and a significant odds ratio (OR; 95% confidence interval, CI) was found (OR = 1.70, 95%CI = 1.06-2.73). Individuals carrying T allele were associated with higher risk of breast cancer when compared with C allele (OR = 1.34, 95%CI = 1.06-1.70). We did not find a significant effect of the MTHFR A1298C and MTR A2756G on the risk of breast cancer. We did not find any association between folate intake and MTHFR C677T polymorphisms. In conclusion, we found that the MTHFR C667T polymorphism is associated with the risk of breast cancer, indicating that this genotype plays a role in breast cancer development. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 4 |
| Volume Number | 13 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2014-10-31 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | 5-methyltetrahydrofolate-homocysteine S-methyltransferase Genetics Breast Neoplasms Folic Acid Administration & Dosage Genetic Predisposition To Disease Methylenetetrahydrofolate Reductase (nadph2) Polymorphism, Single Nucleotide Alleles Metabolism Dietary Supplements Gene Frequency Genotype Odds Ratio Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Risk Factors Vitamin B 12 Vitamin B 6 Vitamins Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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