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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ling, K. Liu, L. Huang, L. W. Zhou, H. C. He, C. P. Yan, Y. Wang, X. M. Zhou, J. Wen, Q. M. |
| Description | Country affiliation: China Author Affiliation: Liu L ( Department of Infectious Disease, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, China.); Yan Y ( Tongji Medical College of Huazhong University of Science and Technology School of Medicine and Health Management, Wuhan, China.); Zhou J ( Department of Infectious Disease, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, China llzjchina@126.com.); Huang LW ( Department of Infectious Disease, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, China.); He CP ( Department of Infectious Disease, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, China.); Ling K ( Department of Infectious Disease, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, China.); Zhou HC ( Department of Infectious Disease, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, China.); Wen QM ( Department of Infectious Disease, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, China.); Wang XM ( Department of Infectious Disease, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, China.) |
| Abstract | This study assessed the clinical efficacy of lamivudine and adefovir dipivoxil combined with autologous bone marrow stem cell transplantation as treatment for patients with hepatitis B and decompensated liver cirrhosis. In total, 77 patients with hepatitis B and decompensated liver cirrhosis were randomly divided into two groups. Under general symptomatic and supportive treatment, the patients in group A (37 cases) were treated with lamivudine and adefovir dipivoxil, whereas those in group B (40 cases) were treated with autologous bone marrow stem cell transplantation in combination with lamivudine and adefovir dipivoxil. After 4 weeks of treatment, the liver function indicators and clinical signs and symptoms of the patients in group B improved more significantly than those of patients in group A. Lamivudine and adefovir dipivoxil in combination with autologous bone marrow stem cell transplantation effectively prevented hepatitis B virus infection and bone marrow stem cell damage. This combination treatment facilitates the differentiation of bone marrow stem cells into normal liver cells to restore liver structure and improve liver function, thereby improving the quality of life of patients. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 4 |
| Volume Number | 13 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2014-02-21 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Adenine Analogs & Derivatives Hepatitis B Virus Drug Effects Lamivudine Therapeutic Use Liver Cirrhosis Drug Therapy Virology Organophosphonates Stem Cell Transplantation Adverse Effects Pharmacology Cholinesterases Metabolism Combined Modality Therapy Physiopathology Liver Function Tests Prothrombin Time Alpha-fetoproteins Randomized Controlled Trial Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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