NDLI: Breast cancer risk, dietary intake, and methylenetetrahydrofolate reductase (MTHFR)single nucleotide polymorphisms.

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Breast cancer risk, dietary intake, and methylenetetrahydrofolate reductase (MTHFR)single nucleotide polymorphisms.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Alshatwi, Ali A.
Description	Country affiliation: Saudi Arabia Author Affiliation: Alshatwi AA ( Molecular Cancer Biology Research Lab, Dept. of Food Science and Nutrition, King Saud University, Saudi Arabia. alialshatwi@gmail.com)
Abstract	Diet plays an important role in DNA methylation, synthesis, and repair; intake has been associated with breast cancer. The folate-metabolizing enzyme, methylenetetrahydrofolate reductase (MTHFR) is polymorphic at nucleotides 677 (C-->T), resulting in allozymes with altered activity and is thus believed to cause interindividual differences in cancer risk susceptibility. I evaluated this polymorphism and its effect on the food intake and breast cancer risk association in a population-based case-control study of 100 breast cancer cases and 100 controls using a real-time PCR based assay. All subjects completed in-person interviews, which included a food-frequency questionnaire. Unconditional logistic regression models were used to calculate odds ratios and their 95% confidence intervals, after adjusting for potential confounding factors. Cases and controls were similar in the distribution ofMTHFRpolymorphisms at codon 677 (41.4% cases and 41.8% controls carried theTallele). An inverse association of breast cancer risk with food intake was observed in all genotype groups, particularly among subjects with the677TTgenotype. Compared with those with the677CCgenotype and high food intake frequency, the adjusted odds ratios (95% confidence intervals) associated with low food intake were 1.94 (1.15-3.26), 2.17 (1.34-3.51), and 2.51 (1.37-4.60) for subjects who hadCC,CT, andTTgenotypes (Pfor interaction, 0.05). Results of this study suggest that theMTHFR C677T polymorphism may modify the association between dietary intake and breast cancer risk.
File Format	HTM / HTML
ISSN	02786915
Issue Number	7
Volume Number	48
e-ISSN	18736351
Journal	Food and Chemical Toxicology
Language	English
Publisher	Elsevier
Publisher Date	2010-07-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology__semicolon__nutritional Discipline Sciences Breast Neoplasms Epidemiology Genetics Diet Methylenetetrahydrofolate Reductase (nadph2) Dna Female Folic Acid Genotype Humans Middle Aged Odds Ratio Polymorphism, Single Nucleotide Risk Questionnaires Vitamins Journal Article Randomized Controlled Trial
Content Type	Text
Resource Type	Article
Subject	Medicine Toxicology Food Science

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