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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | He, J. F. Zhang, W. X. Zhang, Z. Q. Zhang, Z. M. Shi, B. Y. Zhou, W. |
| Description | Country affiliation: China Author Affiliation: Zhang WX ( Department of Nephrology, PLA 309th Hospital, Beijing, China.); Zhou W ( Department of Nephrology, PLA 309th Hospital, Beijing, China.); Zhang ZM ( Department of Nephrology, PLA 309th Hospital, Beijing, China.); Zhang ZQ ( Department of Nephrology, PLA 309th Hospital, Beijing, China.); He JF ( Department of Laboratory Test, PLA 309th Hospital, Beijing, China.); Shi BY ( PLA Institute of Transplantation, PLA 309th Hospital, Beijing, China bingyishi@yeah.net.) |
| Abstract | Retinol-binding protein 4 (RBP4) is a novel adipokine that has been associated with insulin resistance and type 2 diabetes. Patients with end-stage renal disease (ESRD) have very high serum RBP4 levels. However, whether successful kidney transplantation alleviates these elevated serum RBP4 levels is unclear. The serum RBP4 levels of 24 ESRD patients were determined before transplantation and at 1 day, 1 week, and 1 month after kidney transplantation. The control group included 22 healthy subjects. Serum RBP4 concentrations were measured using a commercial kit via the immunologic turbidimetric method, and were related to biomarkers for renal and liver function. The serum RBP4 level of ESRD patients before kidney transplantation (160.8 ± 29.1 mg/L) was approximately 7-fold higher than that of normal controls (22.6 ± 11.0 mg/L; P = 0.000). The serum RBP4 level before transplantation was significantly higher than that at 1 day (65.3 ± 28.4 mg/L), 1 week (48.3 ± 22.9 mg/L), and 1 month after transplantation (53.1 ± 25.5 mg/L; P = 0.000). However, these values were still higher than those of controls (P = 0.000). Univariate regression analysis showed that the percent changes in serum RBP4 concentration before and after kidney transplantation were positively correlated with serum creatinine, blood urea nitrogen, phosphate, and pre-albumin concentrations and negatively correlated with the estimated glomerular filtration rate. The serum RBP4 concentration of patients with ESRD decreased significantly after kidney transplantation; therefore, we found that serum RBP4 concentration was related to renal function. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 4 |
| Volume Number | 13 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2014-10-07 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Kidney Failure, Chronic Blood Retinol-binding Proteins, Plasma Metabolism Adolescent Biological Markers Case-control Studies Physiopathology Therapy Kidney Function Tests Kidney Transplantation Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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