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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wang, Juan Xu, Mengxue Cheng, Xiaojie Kong, Ming Liu, Ya Feng, Chao Chen, Xiguang |
| Description | Author Affiliation: Wang J ( College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao, 266003, Shandong, PR China.); Xu M ( College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao, 266003, Shandong, PR China.); Cheng X ( College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao, 266003, Shandong, PR China.); Kong M ( College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao, 266003, Shandong, PR China.); Liu Y ( College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao, 266003, Shandong, PR China.); Feng C ( College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao, 266003, Shandong, PR China. Electronic address: fengchao@ouc.edu.cn.); Chen X ( College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao, 266003, Shandong, PR China. Electronic address: xgchen@ouc.edu.cn.) |
| Abstract | To develop insulin delivery system for the treatment of diabetes, two insulin-loaded nanogels with opposite zeta potential (-15.94 ± 0.449 mV for insulin:CMCS/CS-NGs(-) and +17.15 ± 0.492 mV for insulin:CMCS/CS-NGs(+)) were obtained. Ex vivo results showed that the nanogels with opposite surface charge exhibited different adhesion and permeation in specific intestinal segments. There was no significant differences in adhesion and permeation in rat duodenum, but in rat jejunum, insulin:CMCS/CS-NGs(-) exhibited enhanced adhesion and permeation, which were about 3 folds (adhesion) and 1.7 folds (permeation) higher than insulin:CMCS/CS-NGs(+). These results demonstrated that the surface charge property of nanogels determined the absorption sites of CMCS/CS-NGs in small intestine. In vivo study, the blood glucose level in insulin:CMCS/CS-NGs(-) group had 3 mmol/L lower than insulin:CMCS/CS-NGs(+) group during 1h to 11h after the oral administration, which demonstrated that negative insulin:CMCS/CS-NGs had a better management of blood glucose than positive ones. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Volume Number | 136 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-01-20 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Chitosan Analogs & Derivatives Drug Carriers Chemistry Gels Insulin Administration & Dosage Administration, Oral Animals Caco-2 Cells Adverse Effects Humans Pharmacokinetics Intestinal Absorption Intestine, Small Metabolism Rats Static Electricity Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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