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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kawata, Mari Azuma, Kazuo Izawa, Hironori Morimoto, Minoru Saimoto, Hiroyuki Ifuku, Shinsuke |
| Description | Country affiliation: Japan Author Affiliation: Kawata M ( Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8552, Japan.); Azuma K ( Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8553, Japan.); Izawa H ( Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8552, Japan.); Morimoto M ( Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8552, Japan.); Saimoto H ( Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8552, Japan.); Ifuku S ( Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8552, Japan. Electronic address: sifuku@chem.tottori-u.ac.jp.) |
| Abstract | We previously reported a chitin nanofiber hydrogel from squid pen ß-chitin by a simple NaOH treatment. In the present study, a calcium phosphate/chitin nanofiber hydrogel was prepared for bone tissue engineering. Calcium phosphate was mineralized on the hydrogel by incubation in a solution of diammonium hydrogen phosphate solution followed by calcium nitrate tetrahydrate. X-ray diffractometry and Fourier transform infrared spectroscopy showed the formation of calcium phosphate crystals. The morphology of the calcium phosphate crystals changed depending on the calcification time. After mineralization, the mechanical properties of the hydrogel improved due to the reinforcement effect of calcium phosphate crystal. In an animal experiment, calcium phosphate/chitin nanofiber hydrogel accelerated mineralization in subcutaneous tissues. Morphological osteoblasts were observed. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Volume Number | 136 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-01-20 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Bone Regeneration Calcification, Physiologic Calcium Phosphates Chemistry Chitin Analogs & Derivatives Hydrogels Nanofibers Tissue Scaffolds Animals Rats Rats, Sprague-dawley Tissue Engineering Methods Adverse Effects Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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