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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lim, Ji-Ho You, Sung-Kyun Baek, Jong-Suep Hwang, Chan-Ju Na, Young-Guk Shin, Sang-Chul Cho, Cheong-Weon |
| Description | Country affiliation: South Korea Author Affiliation: Lim JH ( College of Pharmacy and Institute of Drug Research & Development, Chungnam National University, 220 Gungdong, Yuseonggu, Daejeon 305-764, South Korea.) |
| Abstract | Gemcitabine microparticles were prepared using chitosan, polyethylene oxide or carbopol as the mucoadhesive polymer and eudragit L100-55 as the enteric polymer by a double emulsion method. The particle size and zeta potential changed from 1338.3 ± 254.1 nm to 2459.4 ± 103.6 nm and -5.16 ± 1.62 mV to 2.84 ± 0.65 mV, respectively, with increasing chitosan to gemcitabine weight ratio from 0.25 to 1. The gemcitabine-loaded microparticles without mucoadhesive polymer (F50) showed the particle size and zeta potential of 671.3 ± 58.3 nm and - 16.7 ± 1.82 mV, respectively. The cellular uptake of gemcitabine into Caco-2 cells from gemcitabine-loaded microparticles with chitosan increased with increasing incubation time in Caco-2 cells compared to that of gemcitabine-loaded microparticles with polyethylene oxide or carbopol, suggesting that chitosan might be the optimal mucoadhesive polymer. Gemcitabine microparticles will be tested to identify whether the oral absorption could be increased in the future. |
| File Format | HTM / HTML |
| ISSN | 02652048 |
| Issue Number | 5 |
| Volume Number | 29 |
| e-ISSN | 14645246 |
| Journal | Journal of Microencapsulation |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2012-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Antimetabolites, Antineoplastic Administration & Dosage Chitosan Chemistry Deoxycytidine Analogs & Derivatives Drug Carriers Polyethylene Glycols Polyvinyls Acrylic Resins Administration, Oral Pharmacokinetics Caco-2 Cells Humans Microspheres Particle Size Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Colloid and Surface Chemistry Physical and Theoretical Chemistry Bioengineering Pharmaceutical Science |
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