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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Park, Hee Jun Lee, Ga Hyeon Jun, Joon-Ho Son, Miwon Choi, Yong Seok Choi, Min-Koo Kang, Myung Joo |
| Description | Author Affiliation: Park HJ ( Dong-A ST Research Institute, Pharmaceutical Product Research Laboratories, Giheung-gu, Yongin, Gyeonggi 446-905, Korea.); Lee GH ( Dong-A ST Research Institute, Pharmaceutical Product Research Laboratories, Giheung-gu, Yongin, Gyeonggi 446-905, Korea.); Jun JH ( Dong-A ST Research Institute, Pharmaceutical Product Research Laboratories, Giheung-gu, Yongin, Gyeonggi 446-905, Korea.); Son M ( Dong-A ST Research Institute, Pharmaceutical Product Research Laboratories, Giheung-gu, Yongin, Gyeonggi 446-905, Korea.); Choi YS ( College of Pharmacy, Dankook University, 119 Dandae-ro, Dongnam-gu, Cheonan, Chungnam 330-714, Korea.); Choi MK ( College of Pharmacy, Dankook University, 119 Dandae-ro, Dongnam-gu, Cheonan, Chungnam 330-714, Korea.); Kang MJ ( College of Pharmacy, Dankook University, 119 Dandae-ro, Dongnam-gu, Cheonan, Chungnam 330-714, Korea. Electronic address: kangmj@dankook.ac.kr.) |
| Abstract | The aim of this study was to formulate probiotics-encapsulated pellets with hydroxypropyl methylcellulose acetate succinate (HPMCAS) using a dry powder coating technique to improve the storage stability, acid resistance, and intestinal adherence of viable bacteria (Lactobacillus acidophilus and Bifidobacteria animalis ssp. Lactis). Dry coated pellet (DCP) loaded with probiotics was optimized with respect to the quantity of the HPMCAS, an enteric coating polymer (108 mg), and the kinds and amounts of plasticizer (triethyl citrate, 15.7 mg; acetylated monoglyceride, 6.8 mg), by evaluating the survival rate of the bacteria during preparation process and in an acidic medium. Dry coating process allows the whole survivals of living bacteria during preparation process. The DCP formulation exhibited markedly higher acid tolerability and storage stability compared to uncoated viable bacteria. In an in vivo mucosal adherence study in rats, a profound colonization of viable bacteria in the small and large intestine was observed in rats receiving DCP system (p<0.05) compared to rats receiving uncoated probiotics. Moreover, we found that the repeated DCP administration noticeably inhibited intestinal penetration of endotoxin, a potent inflammatory stimulant, from intestinal mucus. The novel DCP system may be an alternative approach for improving bacterial viability in the preparation process and in an acidic medium, and to promote mucosal colonization of probiotic bacteria in the human gut. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Volume Number | 136 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-01-20 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Methylcellulose Analogs & Derivatives Probiotics Administration & Dosage Animals Bifidobacterium Drug Effects Pathogenicity Intestinal Mucosa Metabolism Microbiology Lactobacillus Acidophilus Male Adverse Effects Pharmacology Rats Rats, Sprague-dawley Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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