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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zhao, Wei Kong, Ming Feng, Chao Cheng, Xiaojie Liu, Ya Chen, Xiguang |
| Description | Country affiliation: China Author Affiliation: Zhao W ( College of Marine Life Science, Ocean University of China, 5 No. Yushan Road, Qingdao 266003, Shandong Province, China.); Kong M ( College of Marine Life Science, Ocean University of China, 5 No. Yushan Road, Qingdao 266003, Shandong Province, China. Electronic address: kongming@ouc.edu.cn.); Feng C ( College of Marine Life Science, Ocean University of China, 5 No. Yushan Road, Qingdao 266003, Shandong Province, China.); Cheng X ( College of Marine Life Science, Ocean University of China, 5 No. Yushan Road, Qingdao 266003, Shandong Province, China.); Liu Y ( College of Marine Life Science, Ocean University of China, 5 No. Yushan Road, Qingdao 266003, Shandong Province, China.); Chen X ( College of Marine Life Science, Ocean University of China, 5 No. Yushan Road, Qingdao 266003, Shandong Province, China. Electronic address: xgchen@ouc.edu.cn.) |
| Abstract | The gelling behaviors of thiolated chitosan (TCS) in alkaline condition were investigated. Thioglycolic acid was conjugated onto chitosan backbone through amide bond formation. The variations of thiol group content were monitored in presence of H2O2 or different pH values (pH 7.0, 8.0, 9.0) in dialysis mode. Different from the decreasing thiol group content upon time in acidic condition, increasing amount of thiol groups was detected in alkaline pH during 120 min dialysis attributed to alkaline hydrolysis of intra-molecular disulfide bonds. The extent of which was larger at higher pH values. Higher degree of thiolation, thiomer concentration or pH values promoted gelation of TCS. Entanglement and coagulation of chitosan molecule chains and re-arrangement of disulfide bonds acted closely and dynamically in the gelation process. Disulfide bonds, especially inter-molecular type, are formed by synergetic effects of thiol/disulfide interchange and thiol/thiol oxidation reactions. TCS coated vascular stent displayed wave-like microstructure of parallel ridges and grooves, which favored HUVECs adhesion and proliferation. The biocompatibility, peculiar morphology and thiol moieties of TCS as stent coating material appear application potential for vascular stent. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Volume Number | 136 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-01-20 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Chitosan Chemistry Stents Sulfhydryl Compounds Cell Adhesion Drug Effects Toxicity Gels Human Umbilical Vein Endothelial Cells Cytology Humans Hydrogen Peroxide Hydrogen-ion Concentration Oxidation-reduction Phase Transition Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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