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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ustyuzhanina, Nadezhda E. Bilan, Maria I. Gerbst, Alexey G. Ushakova, Natalia A. Tsvetkova, Eugenia A. Dmitrenok, Andrey S. Usov, Anatolii I. Nifantiev, Nikolay E. |
| Description | Author Affiliation: Ustyuzhanina NE ( N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, B-334, 119991 Moscow, Russian Federation.); Bilan MI ( N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, B-334, 119991 Moscow, Russian Federation.); Gerbst AG ( N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, B-334, 119991 Moscow, Russian Federation.); Ushakova NA ( V.N. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Pogodinskaya Str. 10, 119121 Moscow, Russian Federation.); Tsvetkova EA ( N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, B-334, 119991 Moscow, Russian Federation.); Dmitrenok AS ( N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, B-334, 119991 Moscow, Russian Federation.); Usov AI ( N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, B-334, 119991 Moscow, Russian Federation.); Nifantiev NE ( N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, B-334, 119991 Moscow, Russian Federation. Electronic address: nen@ioc.ac.ru.) |
| Abstract | Selectively and totally sulfated (1 â 3)-linked linear homofucans bearing â¼ 20 monosaccharide residues on average have been prepared from the branched xylofucan sulfate isolated from the brown alga Punctaria plantaginea. Anticoagulant and antithrombotic properties of the parent biopolymer and its derivatives were assessed in vitro. Highly sulfated linear fucan derivatives were shown to inhibit clot formation in APTT assay and ristocetin induced platelets aggregation, while the partially sulfated analogs were inactive. In the experiments with purified proteins, fucan derivatives with degree of sulfation of â¼ 2.0 were found to enhance thrombin and factor Xa inhibition by antithrombin III. The effect of sulfated fucans on thrombin inhibition, which was similar to those of heparinoid Clexane(®) (enoxaparin) and of a fucoidan from the brown alga Saccharina latissima studied previously, can be explained by the multicenter interaction and formation of a ternary complex thrombin-antithrombin III-polysaccharide. The possibility of such complexation was confirmed by computer docking study. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Volume Number | 136 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-01-20 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Anticoagulants Chemistry Plant Extracts Platelet Aggregation Inhibitors Polysaccharides Xylose Analogs & Derivatives Amino Acid Sequence Pharmacology Blood Platelets Drug Effects Humans Molecular Sequence Data Phaeophyta Protein Binding Thrombin Metabolism Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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