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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wang, Guodong Liu, Chunyan Liu, Jun Liu, Bo Li, Ping Qin, Guozheng Xu, Yanghui Chen, Ke Liu, Huixia Chen, Kaoshan |
| Description | Country affiliation: China Author Affiliation: Wang G ( Xiangya Hospital, Central South University, Changsha, Hunan 410008, China); Liu C ( Anhui Provincial Engineering Research Center for Polysaccharide Drugs, Anhui Province Key Laboratory of Active Biological Macro-molecules, School of Pharmacy, Wannan Medical College, Wuhu 241002, China.); Liu J ( Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.); Liu B ( Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.); Li P ( Anhui Provincial Engineering Research Center for Polysaccharide Drugs, Anhui Province Key Laboratory of Active Biological Macro-molecules, School of Pharmacy, Wannan Medical College, Wuhu 241002, China.); Qin G ( Anhui Provincial Engineering Research Center for Polysaccharide Drugs, Anhui Province Key Laboratory of Active Biological Macro-molecules, School of Pharmacy, Wannan Medical College, Wuhu 241002, China.); Xu Y ( Anhui Provincial Engineering Research Center for Polysaccharide Drugs, Anhui Province Key Laboratory of Active Biological Macro-molecules, School of Pharmacy, Wannan Medical College, Wuhu 241002, China.); Chen K ( Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.); Liu H ( Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. Electronic address: lhx900@aliyun.com.); Chen K ( Anhui Provincial Engineering Research Center for Polysaccharide Drugs, Anhui Province Key Laboratory of Active Biological Macro-molecules, School of Pharmacy, Wannan Medical College, Wuhu 241002, China) |
| Abstract | In this study, we reported the anticancer efficacy of exopolysaccharide (EPS) derived from Trichoderma pseudokoningii, on human breast cancer MCF-7 cells. Our results showed that EPS inhibited the proliferation of MCF-7 cells and induced lactic dehydrogenase release by inducing apoptosis and cell arrest at S phase. Further study revealed that EPS-induced apoptosis of MCF-7 cells was associated with alteration of nuclear morphology, disruption of mitochondrial membrane potential and accumulation of intracellular reactive oxygen species. Sequentially, EPS increased the activation of caspase-9 and caspase-3 in a dose-dependent manner; however, caspase-8 remained intact. Western blot analysis revealed that EPS increased the ratio of Bax/Bcl-2 and promoted the release of cytochrome c into the cytoplasm. Taken together, these findings provided evidence that EPS induced the apoptosis of MCF-7 cells through an intrinsic mitochondrial apoptotic pathway and that EPS may therefore be considered as an effective adjuvant agent against human breast cancer. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Volume Number | 136 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-01-20 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Antineoplastic Agents Pharmacology Apoptosis Fungal Polysaccharides Mitochondria Drug Effects Trichoderma Chemistry Humans L-lactate Dehydrogenase Metabolism Mcf-7 Cells S Phase Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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