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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yang, Kaiwen Wan, Sicheng Chen, Binbin Gao, Wenxia Chen, Jiuxi Liu, Miaochang He, Bin Wu, Huayue |
| Description | Country affiliation: China Author Affiliation: Yang K ( College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China.); Wan S ( College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China.); Chen B ( College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China.); Gao W ( College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China. Electronic address: wenxiag@wzu.edu.cn.); Chen J ( College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China.); Liu M ( College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China.); He B ( National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.); Wu H ( College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China. Electronic address: huayuewu@wzu.edu.cn.) |
| Abstract | 2-Methylacrylic acid modified ß-cyclodextrin was copolymerized with 2-methylacrylic acid and N,N'-methylene diacrylamide to fabricate dual pH and temperature responsive hydrogels for the controlled release of atorvastatin. The swelling behaviors, pH and temperature responsive atorvastatin release profiles of the hydrogels were investigated. The results indicated that the hydrogel prepared in DMSO exhibited the best swelling rate, which was 51 for 10 min and 252 for 16 h when immersed in medium of buffer solution with pH=8.06. The media with low (pH ≤ 3.84) and high (pH ≥ 10.34) pH values would reduce the swelling rate of hydrogels. The swelling of the hydrogel was increased with increasing temperature from 30 °C to 45 °C. Atorvastatin was loaded in the hydrogel for drug release investigation. The cumulative release rate of atorvastatin was as high as 90.5% in pH=8.06 buffer solution. The solubility of atorvastatin was improved from 0.13 to 1.2mg/mL in the hydrogel. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Volume Number | 136 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-01-20 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Atorvastatin Calcium Chemistry Drug Carriers Hydrogels Temperature Beta-cyclodextrins Delayed-action Preparations Hydrogen-ion Concentration Methacrylates Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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