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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jalaja, K. Naskar, Deboki Kundu, Subhas C. James, Nirmala R. |
| Description | Country affiliation: India Author Affiliation: Jalaja K ( Department of Chemistry, Indian Institute of Space Science and Technology, Thiruvananthapuram 695 547, Kerala, India.); Naskar D ( Department of Biotechnology, Indian Institute of Technology Kharagpur, 721302 West Bengal, India.); Kundu SC ( Department of Biotechnology, Indian Institute of Technology Kharagpur, 721302 West Bengal, India.); James NR ( Department of Chemistry, Indian Institute of Space Science and Technology, Thiruvananthapuram 695 547, Kerala, India. Electronic address: nirmala@iist.ac.in.) |
| Abstract | Coaxial electrospinning is an upcoming technology that has emerged from the conventional electrospinning process in order to realize the production of nanofibers of less spinnable materials with potential applications. The present work focuses on the production of chitosan nanofibers in a benign route, using natural polymer as core template, mild solvent system and naturally derived cross-linkers. Nanofibers with chitosan as shell are fabricated by coaxial electrospinning with highly spinnable gelatin as core using aqueous acetic acid as solvent. For maintaining the biocompatibility and structural integrity of the core-shell nanofibers, cross-linking is carried out using naturally derived cross-linking agents, dextran aldehyde and sucrose aldehyde. The biological evaluation of gelatin/chitosan mat is carried out using human osteoblast like cells. The results show that the cross-linked core-shell nanofibers are excellent matrices for cell adhesion and proliferation. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Volume Number | 136 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-01-20 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Biocompatible Materials Chemistry Pharmacology Chitosan Electricity Gelatin Nanofibers Nanotechnology Cell Adhesion Drug Effects Cell Line Cell Proliferation Dextrans Glutaral Humans Mechanical Phenomena Osteoblasts Cytology Oxidation-reduction Solvents Sucrose Temperature Tissue Scaffolds Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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