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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Shevchenko, Natalia M. Anastyuk, Stanislav D. Menshova, Roza V. Vishchuk, Olesya S. Isakov, Vladimir I. Zadorozhny, Pavel A. Sikorskaya, Tatiana V. Zvyagintseva, Tatiana N. |
| Description | Author Affiliation: Shevchenko NM ( G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 100 Let Vladivostoku prosp. 159, 690022 Vladivostok, Russian Federation.); Anastyuk SD ( G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 100 Let Vladivostoku prosp. 159, 690022 Vladivostok, Russian Federation.); Menshova RV ( G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 100 Let Vladivostoku prosp. 159, 690022 Vladivostok, Russian Federation. Electronic address: Menshova-R@yandex.ru.); Vishchuk OS ( G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 100 Let Vladivostoku prosp. 159, 690022 Vladivostok, Russian Federation.); Isakov VI ( G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 100 Let Vladivostoku prosp. 159, 690022 Vladivostok, Russian Federation.); Zadorozhny PA ( Institute of Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 100 Let Vladivostoku prosp. 159, 690022 Vladivostok, Russian Federation.); Sikorskaya TV ( G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 100 Let Vladivostoku prosp. 159, 690022 Vladivostok, Russian Federation); Zvyagintseva TN ( G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 100 Let Vladivostoku prosp. 159, 690022 Vladivostok, Russian Federation.) |
| Abstract | A sulfated galactofucan SgF (MW 123kDa) was purified from the brown alga Saccharina gurjanovae. Polysaccharide was depolymerized by autohydrolysis at 25 and 60°C, and products were studied by mass spectrometry and (13)C NMR spectroscopy. According to results of investigation, the main chain of this polysaccharide is built of a repeating units â3)- -L-Fucp-(2,4-OSO3(-))-(1â. Fucose chains could be sometimes terminated by (1â3)-linked galactose residues. Shorter (1â4)- and/or (1â6)-linked sulfated galactose chains are attached at positions C-2, C-3 of fucose residues. Sulfate groups can occupy positions C-2 and/or sometimes C-3 of Gal residues, but a sulfation at C-4 of the galactofucan could not be excluded. The SgF-AH25-H preparation (71kDa) was obtained by autohydrolysis of SgF at 25°C, which leaded to a selective desulfation at C-2 and, probably, to a cleavage of galactose chains, since structure of SgF-AH25-H represented a repeating unit â3)- -l-Fucp-(4-OSO3(-))-(1â, which was definitely established by (13)C NMR spectroscopy. Galactofucan SgF and its derivative SgF-AH25-H exhibited no cytotoxic activity and leaded to about the same colony formation inhibition in colon cancer DLD-1 cells. Hence, structural simplification of SgF by lowering its molecular weight, desulfation at C-2 and removing of galactose residues by autohydrolysis at 25°C did not decrease its anticancer activity. This procedure allows obtaining standardized products which can be used as medical. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Volume Number | 121 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-05-05 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Antineoplastic Agents Chemistry Phaeophyta Polysaccharides Pharmacology Carbohydrate Sequence Cell Line, Tumor Humans Molecular Sequence Data Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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