Please wait, while we are loading the content...
Please wait, while we are loading the content...
| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pedotti, Sonia Pistarà, Venerando Cannavà, Carmela Carbone, Claudia Cilurzo, Felisa Corsaro, Antonino Puglisi, Giovanni Ventura, Cinzia Anna |
| Description | Country affiliation: Italy Author Affiliation: Pedotti S ( CNR-Istituto di Chimica Biomolecolare, Via Paolo Gaifami 18, I-95126 Catania, Italy.); Pistarà V ( Dipartimento di Scienze del Farmaco, Università di Catania, Viale A. Doria 6, I-95125 Catania, Italy. Electronic address: vpistara@unict.it.); Cannavà C ( Dipartimento di Patologia Umana, Università di Messina, Policlinico Universitario, Pad. H, Via Consolare Valeria 1, I-98125 Messina, Italy.); Carbone C ( Dipartimento di Scienze del Farmaco, Università di Catania, Viale A. Doria 6, I-95125 Catania, Italy.); Cilurzo F ( Dipartimento di Scienze della Salute, Università 'Magna Græcia' di Catanzaro, Viale Europa, I-88100 Catanzaro, Italy.); Corsaro A ( Dipartimento di Scienze del Farmaco, Università di Catania, Viale A. Doria 6, I-95125 Catania, Italy.); Puglisi G ( Dipartimento di Scienze del Farmaco, Università di Catania, Viale A. Doria 6, I-95125 Catania, Italy.); Ventura CA ( Dipartimento di Scienze del Farmaco e dei Prodotti per la Salute (SCIFAR), Università di Messina, Viale Annunziata, I-98168 Messina, Italy. Electronic address: caventura@unime.it.) |
| Abstract | We report the synthesis of an oligomeric prodrug of the antiviral agent Acyclovir (Acy) conjugated to ß-cyclodextrin (ß-CyD). The drug was selectively linked through a succinic spacer to one of the primary hydroxyl groups of ß-CyD by ester linkage in a 1:1 molar ratio. The conjugate was purified by semipreparative reverse-phase chromatography and characterized by FAB mass spectrometry and NMR experiments. The release of Acy from the conjugate was evaluated both in acidic and in neutral conditions and in the presence of porcine liver esterase. In all cases we observed the release of both free Acy and Acy succinate (AcySucc) at differing rates as a function of the hydrolysis conditions. In the presence of esterase the release of free Acy was favoured over AcySucc, showing a release rate of 100% of Acy within 7 days. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Volume Number | 131 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-10-20 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Acyclovir Pharmacology Chemical Phenomena Drug Liberation Beta-cyclodextrins Chemistry Chemical Synthesis Chromatography, High Pressure Liquid Delayed-action Preparations Hydrogen-ion Concentration Hydrolysis Kinetics Time Factors Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|