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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Stern, E. Vacic, A. Rajan, N.K. Criscione, J.M. Park, J. Fahmy, T.M. Reed, M.A. |
| Copyright Year | 2010 |
| Description | Author affiliation: Yale University, School of Engineering and Applied Science, Departments of Electrical, USA (Vacic, A.; Rajan, N.K.) || Yale University, School of Engineering and Applied Science, Departments of Biomedical, USA (Stern, E.; Criscione, J.M.; Park, J.; Fahmy, T.M.; Reed, M.A.) |
| Abstract | Label-free nanosensors can detect disease markers to provide point-of-care diagnosis that is low-cost, rapid, specific and sensitive. However, detecting these biomarkers in physiological fluid samples is difficult because of ionic screening. Here, we overcome this limitation by using distinct components within the sensor to perform purification and $detection.^{1}$ A microfluidic purification chip captures multiple biomarkers simultaneously from blood samples and releases them, after washing, into purified buffer for sensing by a silicon nanoribbon detector. This two-stage approach isolates the detector from the complex environment of whole blood, and reduces its minimum required sensitivity by effectively pre-concentrating the biomarkers. We show specific and quantitative detection of two model cancer antigens from a 10 uL sample of whole blood in less than 20 minutes. |
| Starting Page | 1392 |
| Ending Page | 1393 |
| File Size | 382813 |
| Page Count | 2 |
| File Format | |
| ISBN | 9781424457977 |
| e-ISBN | 9781424457984 |
| DOI | 10.1109/ICSICT.2010.5667621 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2010-11-01 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Blood Performance evaluation Purification Detectors Microfluidics Fluids |
| Content Type | Text |
| Resource Type | Article |
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