NDLI: Polymer-based microfluidic devices for rare cell detection by ultrasounds

Content Provider	IEEE Xplore Digital Library
Author	Itziar, G. Acosta, V. Castillejo, A. Soto, J.L. Tijero, M. Berganzo, J. Martin, A. Bouali, M.
Copyright Year	2013
Description	Author affiliation: Dept. of Ultrasounds, CSIC, Madrid, Spain (Itziar, G.; Acosta, V.) \|\| Group of fluidics, Univ. Politec. Mondragon, Mondragón, Spain (Martin, A.; Bouali, M.) \|\| Dept. Microsyst., IKERLAN, Mondragon, Spain (Tijero, M.; Berganzo, J.) \|\| Dept. Mol. Biol., Hosp. GU ElcheElche, Elche, Spain (Castillejo, A.; Soto, J.L.)
Abstract	A low-cost technological approach based on the strategic application of ultrasonic waves on polymeric chips has been developed to detect and extract circulating tumor cells from peripheral blood samples flowing through the microfluidic device, which are delivered viable for later biomolecular analyses. This free-label technique can be used as an early detection system to identify metastasis in the initial stages, assuming a very low number of rare cells present in the blood sample, less than 5 cells/7.5mL. We have demonstrated the feasibility of separation of the tumor cells utilizing hydrodynamic forces induced by ultrasounds in polymeric chips delivering viable single cells and multicellular clusters which differentially experience a drift motion as they flow through a microchannel in a sample containing white blood cells.
Starting Page	1
Ending Page	4
File Size	371475
Page Count	4
File Format	PDF
ISBN	9781467346429
ISSN	19300395
DOI	10.1109/ICSENS.2013.6688606
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-11-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Acoustics Tumors Blood Ultrasonic imaging Polymers Force Trajectory
Content Type	Text
Resource Type	Article
Subject	Electrical and Electronic Engineering

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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