NDLI: Integrated electrochemical sensor based on electrowetting-on-dielectric microfluidic chip

Content Provider	IEEE Xplore Digital Library
Author	Jianfeng Chen Yuhua Yu Jia Zhou
Copyright Year	2013
Description	Author affiliation: Dept. of Microelectron., Fudan Univ., Shanghai, China (Jianfeng Chen; Yuhua Yu; Jia Zhou)
Abstract	In this work, we describe the design and study of a novel electrochemical microsensor integrated with electrowetting-on-dielectric (EWOD) microfluidic chip for automatic, rapid and microscale detection. The microsensor was based on the parallel plate EWOD chip. The pretreatment of microliter analyte including dispensing, transporting, mixing and colleting was realized mainly by EWOD electrodes on the bottom plate. The top plate consists of the ground wires for EWOD microfluidics and an on-chip electrochemical cell with gold three-electrode system. The structure and fabrication process were optimized to improve the reliability and stability of integrated chip. The chip can simultaneously realize multifunctional manipulation and online electrochemical detection for reagent droplets. It shows a wide linear range of 10.0 μM-1.0 mM ferrocenemethanol (FcM). The sensitivity of anodic and cathodic peak current was about 5.47 nA/μM $(R^{2}=0.99994)$ and 5.21 nA/μM $(R^{2}=0.99904),$ respectively. This work shows a great promise for microliter biosensing based on smart microfluidic unit and integrated electrochemical cell in the future.
Starting Page	1
Ending Page	4
File Size	790622
Page Count	4
File Format	PDF
ISBN	9781467346429
ISSN	19300395
DOI	10.1109/ICSENS.2013.6688236
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-11-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Electrodes Microfluidics Surface treatment Substrates Gold Fabrication Biosensors
Content Type	Text
Resource Type	Article
Subject	Electrical and Electronic Engineering

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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