NDLI: Microfluidics-based acoustic microbubble biosensor

Content Provider	IEEE Xplore Digital Library
Author	Ying Zhou Seshia, A.A. Hall, E.A.H.
Copyright Year	2013
Description	Author affiliation: Dept. of Chem. Eng. & Biotechnol., Univ. of Cambridge, Cambridge, UK (Hall, E.A.H.) \|\| Dept. of Eng., Univ. of Cambridge, Cambridge, UK (Ying Zhou; Seshia, A.A.)
Abstract	This paper proposes a chip-scale microbubble-based biosensing platform. An encapsulated microbubble oscillates acoustically in liquid when exposed to an ultrasound field with its resonant frequency set by shell parameters. Changes in the resonant frequency of the microbubble can be used to monitor analyte-binding events on the shell. A device concept is proposed where ultrasonic transducers are integrated within a microfluidic channel, inside which electrodes are patterned for differential measurements of microbubble impedance. This device enables simultaneous measurements of the acoustic and electrical response of the microbubble, from which both mechanical and electrical parameters can be extracted. These parameters are used to provide a signature of the analyte. This paper presents acoustic and electrical models of the microbubbles, with the effect of shell parameters being thoroughly discussed.
Starting Page	1
Ending Page	4
File Size	1305034
Page Count	4
File Format	PDF
ISBN	9781467346429
ISSN	19300395
DOI	10.1109/ICSENS.2013.6688408
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-11-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Acoustics Resonant frequency Impedance Biosensors Liquids Impedance measurement Viscosity
Content Type	Text
Resource Type	Article
Subject	Electrical and Electronic Engineering

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