NDLI: Liquid heating can cause denaturation of sensing layer in SAW biosensors

Content Provider	IEEE Xplore Digital Library
Author	Suthar, K.J. Sankaranarayanan, S.K.R.S. Richardson, M. Bhethanabotla, V.R.
Copyright Year	2013
Description	Author affiliation: Center for Nanoscale Mater., Argonne Nat. Lab., Argonne, IL, USA (Suthar, K.J.; Sankaranarayanan, S.K.R.S.) \|\| Dept. of Chem. & Biomed. Eng., Univ. of South Florida, Tampa, FL, USA (Richardson, M.; Bhethanabotla, V.R.)
Abstract	The acoustic streaming phenomenon, i.e., fluid motion induced from high intensity sound waves, can be used effectively to remove nonspecifically bound proteins to allow reuse of SAW biosensors. While the streaming effect is clearly beneficial, this longitudinal irradiation into the fluid medium can also be accompanied by a corresponding temperature rise of the fluid near the SAW interface due to viscous dissipation, which can lead to denaturation of biosensing layer. Finite element solution of coupled wave propagation (piezoelectric domain) and Navier-Stokes equation (fluid domain) in conjunction with the energy balance equations were used to model the temperature rise of a liquid loading on top of a SAW device. Based on the temperature profiles, we identify the conditions that preserve the activity of the sensing layer as well as those leading to significant heating of the fluid domain. Our computational study highlights the fact that such increase in temperatures of the interfacial liquid layer can have significant implications for designing reusable and highly sensitive biosensors.
Starting Page	1
Ending Page	4
File Size	1226203
Page Count	4
File Format	PDF
ISBN	9781467346429
ISSN	19300395
DOI	10.1109/ICSENS.2013.6688383
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-11-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Heating Mathematical model Liquids Surface acoustic waves Surface acoustic wave devices Finite element method Liquid heating Acoustic streaming SAW Biofouling
Content Type	Text
Resource Type	Article
Subject	Electrical and Electronic Engineering

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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