NDLI: Photometric aptasensor using biofunctionalized photonic crystal slabs

Content Provider	IEEE Xplore Digital Library
Author	Jahns, S. Nazirizadeh, Y. Meyer, B.-O. Gerken, M. Gutekunst, S.B. Selhuber-Unkel, C.
Copyright Year	2013
Description	Author affiliation: Inst. of Mater. Sci., Christian-Albrechts-Univ. zu Kiel, Kiel, Germany (Gutekunst, S.B.; Selhuber-Unkel, C.) \|\| Inst. of Electr. & Inf. Eng., Christian-Albrechts-Univ. zu Kiel, Kiel, Germany (Jahns, S.; Nazirizadeh, Y.; Meyer, B.-O.; Gerken, M.)
Abstract	We present a biosensor using a photonic crystal slab (PCS) surface-functionalized with aptamers (thus aptasensor) and a label-free photometric detection scheme. Resonances in the optical transmission spectrum of the PCS are highly sensitive to mass changes on the surface of the PCS. We align the resonance's spectral position to the falling edge of a light emitting diode's (LED) spectrum and use two crossed polarization filters before and after the PCS. Thus, we may detect a molecular binding process on the surface of the PCS with a simple photometric intensity measurement. Using a CMOS camera, we determine the signal and reference intensity at different positions on the PCS. The functionality of this aptasensor is demonstrated by applying a 125 nM thrombin-solution to the PCS bio-functionalized with anti-thrombin aptamers. A significant signal was obtained and the reaction kinetic was observed.
Starting Page	1
Ending Page	3
File Size	745758
Page Count	3
File Format	PDF
ISBN	9781467346429
ISSN	19300395
DOI	10.1109/ICSENS.2013.6688384
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-11-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Optical surface waves Photonic crystals Biomedical optical imaging Optical sensors Optical variables control Biosensors Optical filters
Content Type	Text
Resource Type	Article
Subject	Electrical and Electronic Engineering

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