NDLI: CMOS chip for electrochemical monitoring of the metabolic activity of biological cells

Content Provider	IEEE Xplore Digital Library
Author	Rothe, J. Frey, O. Stettler, A. Yihui Chen Hierlemann, A.
Copyright Year	2012
Description	Author affiliation: ETH Zurich, Bio Engineering Laboratory, Mattenstrasse 26 Basel, Switzerland (Rothe, J.; Frey, O.; Stettler, A.; Yihui Chen; Hierlemann, A.)
Abstract	An integrated CMOS chip for performing electrochemical experiments, which can continuously monitor the metabolic activity of biological cells, is presented. The chip comprises an array of 1024 platinum working electrodes, 64 current readout channels, an integrated potentiostat with on-chip counter, as well as reference electrodes and a temperature sensor. Two different sigma-delta analog-to-digital converters are implemented to realize the current measurement. The first-order sigma-delta converter has a linearity and resolution of better than 11 bits, whereas the second-order sigma-delta converter achieves a resolution and linearity of better than 12 bits. The current range can be set from 2 μA down to 100 pA. The chip package comprises small wells for the cells and reservoirs for the culture media; moreover, it protects the electrical connections. Proof-of-concept measurements of glucose concentrations are shown.
Starting Page	1
Ending Page	4
File Size	534582
Page Count	4
File Format	PDF
ISBN	9781457717666
ISSN	19300395
e-ISBN	9781457717673
e-ISBN	9781457717659
DOI	10.1109/ICSENS.2012.6411351
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-10-28
Publisher Place	Taiwan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Electrodes Sigma delta modulation Sugar Arrays CMOS integrated circuits Capacitors Biosensors
Content Type	Text
Resource Type	Article
Subject	Electrical and Electronic Engineering

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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