NDLI: Closed-loop blood glucose control using dual subcutaneous infusion of insulin and glucagon based on switching PID controller

Content Provider	IEEE Xplore Digital Library
Author	Xiaoteng Gao Youqing Wang
Copyright Year	2012
Description	Author affiliation: College of Information Science & Technology, Beijing University of Chemical Technology, China (Xiaoteng Gao; Youqing Wang)
Abstract	Glucose management is an important clinical task for diabetic patients, and intensive insulin therapy is widely considered a promising way for the glucose management. However, the intensive insulin therapy has one potential risk: hypoglycemia, but there is no antagonist to compensate hypoglycaemia in the intensive insulin therapy. Dual infusion of insulin and glucagon can overcome this shortcoming. In this paper, a switching control algorithm was proposed to design and optimize the insulin and glucagon infusion rates simultaneously, and this algorithm has been implemented in a virtual type 1 diabetic subject. The in silico results demonstrate that the proposed algorithm can reduce hypoglycaemia significantly.
Starting Page	5023
Ending Page	5029
File Size	249461
Page Count	7
File Format	PDF
ISBN	9781467313971
e-ISBN	9781467313988
DOI	10.1109/WCICA.2012.6359430
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-07-06
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Insulin Sugar Switches Diabetes Robustness glucose management switching control IMC-PID hypoglycaemia switching rule
Content Type	Text
Resource Type	Article

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