NDLI: Nonaqueous capillary electrophoresis in microchip: Influence of solvent properties on separation performance

Content Provider	IEEE Xplore Digital Library
Author	Yue Sun Yang He Shumei Wang Shengwang Liang Guangping Zhu
Copyright Year	2011
Description	Author affiliation: College of Chinese Traditional Medicine, Guangdong Pharmaceutical University, Guangzhou, 510006, China (Yue Sun; Yang He; Shumei Wang; Shengwang Liang; Guangping Zhu)
Abstract	The aim of this study was to simplify the solvent selection for non-aqueous microchip CE by investigating the effect of different organic solvents on the separation speed and resolution of two simple and stable fluorescent dyes. Organic solvents, including methanol (MeOH), acetonitrile (ACN), dimethylsulfoxide (DMSO), formamide (FA) and N,N-dimethylformamide (DMF) were evaluated against water. The electrophoresis behaviors of Rhodamine123 and Fluorescein sodium under different electric field strength were studied systematically in a simple cross microchip. Two models for predicting the resolution and separation speed based on solvent property such as viscosity (η), dielectric constant (ε), and zeta potentials (ς), were generated and tested. The experimental results were in agreement with the theoretical prediction when low separation voltages were applied in most solvents except FA. Solvents with a high ε ς / η will tend to speed up the separation, and solvents with a low ε ς will tend to increase the resolution of the analytes.
Starting Page	8365
Ending Page	8368
File Size	343333
Page Count	4
File Format	PDF
ISBN	9781424491728
e-ISBN	9781424491711
DOI	10.1109/RSETE.2011.5964106
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-06-24
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Water Viscosity Solvents Electric potential Solvent property Separation speed Fluorescence Reservoirs Nonaqueous capillary electrophoresi Microchip Methanol Resolution
Content Type	Text
Resource Type	Article

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