NDLI: An electrophysiological analysis of brainstem function in rats with diabetes mellitus

Content Provider	IEEE Xplore Digital Library
Author	Deshan Liu Wei Gao Weiwei Lin Inoguchi, T. Takayanagi, R.
Copyright Year	2011
Description	Author affiliation: Department of Traditional Chinese Medicine, Qilu Hospital of Shandong University, Jinan, 250012, China (Deshan Liu; Wei Gao; Weiwei Lin) \|\| Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan (Inoguchi, T.; Takayanagi, R.)
Abstract	Diabetes mellitus (DM) can affect both the peripheral and the central nervous system (CNS). However, central deficits are documented less well than peripheral deficits. We believe that brainstem auditory evoked potential (BAEP) studies help in the understanding of the dysfunction of the ascending sensory pathways at various levels. Twenty-two male rats were randomly divided into two groups: normal control rats (group NC) and diabetic rats (group DM). DM was induced by a single intraperitoneal injection of 1% streptozotocin (STZ, 60 mg/kg of body weight) in all rats of DM group. After six weeks, Absolute peak latencies (PLs) of waves I, II, III, IV and V, and interpeak latencies (IPL) of I–III, III–V and I-V were measured in each rats of the experiment. Then serum insulin levels, blood biochemical indices, superoxide dismutase (SOD) and malondialdehyde (MDA) were measured. The diabetic status of the rats of DM group was kept uncontrolled throughout the study. Body weight and blood glucose of non-fasting rats (BG) in DM group were significantly altered than those of NC group (P<0.05, respectively). Neuroelectrophysiological results showed that all wave latencies and IPL I–III, I–V in DM group were prolonged at 6 weeks after induction of diabetes, and delay in waves III, V and IPL I–III, I–V was significant compared with NC group (P<0.05, respectively). It was discovered that central conduction time (CCT) of rats with diabetes had a close correlation with fasting insulin (FINS), fasting blood glucose (FBG) and MDA. These findings indicate that experimentally induced diabetes can result in a brain dysfunction as measured by the increased latencies of the IPL I–V of BAEP. In conclusion, BAEP prove to be a useful non-invasive neuroelectrophysiological technique that may help unravel both the relative involvement of the peripheral and central nervous systems in the course of diabetes mellitus, and the evolution of diabetic neuropathy.
Starting Page	7372
Ending Page	7375
File Size	213613
Page Count	4
File Format	PDF
ISBN	9781424491728
e-ISBN	9781424491711
DOI	10.1109/RSETE.2011.5966072
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-06-24
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Neuroelectrophysiology Rats Delta modulation Biochemistry Diabetes Experimental diabetes Brain dyfunction Brainstem auditory evoked potential Blood Sugar
Content Type	Text
Resource Type	Article

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