NDLI: Bone protective effects and mechanism of Polygonatum Sibiricum Polysaccharide in ovariectomized rat

Content Provider	IEEE Xplore Digital Library
Author	Gaofeng Zeng Zhiyong Zhang Li Lu Deqianj Xiao Shaohui Zong Chunxiang Xiong Yuxi Zhao
Copyright Year	2011
Description	Author affiliation: College of Public Hygiene, Guangxi Medical University, GMU, Nanning, China (Gaofeng Zeng; Zhiyong Zhang; Li Lu; Deqianj Xiao; Shaohui Zong; Chunxiang Xiong; Yuxi Zhao)
Abstract	Objective: To assess the bone protective effects and mechanism of Polygonatum Sibiricum Polysaccharide (PSP) in ovariectomized rat. Methods: 60 female SD rats were randomly separated into 6 groups:control group (n=10); ovariectomized group (OVX) (n=10); the OVX + E2 group(OVX + E2) (n=10); the high-dose OVX + PSP group (OVX + HZ) (n=10); the moderate-dose OVX + PSP group (OVX + MZ) (n=10); the low dose OVX + PSP group (OVX + LZ) (n=10). PSP was administered intragastrically to the rats. After 35 days, the total body Bone mineral density (BMD) was assessed in the rats. All sections were processed for hematoxylin-eosin staining (H.E.), and Basic fibroblast growth factor (bFGF), Tartrate-resistant acid phosphatase (TRAP), Bone morphogenetic proteins (BMP), and Bone Gla protein (BGP) immunoreactivity was assessed. Serum tumor necrosis factor-α (TNF-α) and bone specific alkaline phosphatase (BALP) levels were assessed using commercially available ELISA kits. Results:The expression of BMP and bFGF were significantly increased in OVX+HP. The expression of TRAP, TNF-α, BGP and BALP were significantly decreased in OVX+HP. BMD was significantly increased in OVX+HP(vs. OVX, P<0.05).Conclusion: The results of this experiment demonstrate that PSP can increase the expression of bFGFand BMP while reducing the expression of TRAP, BGP, TNF-α and BALP. The administration of PSP to ovariectomized rats reverses bone loss and prevents osteoporosis.
Starting Page	6653
Ending Page	6658
File Size	1576950
Page Count	6
File Format	PDF
ISBN	9781424491728
e-ISBN	9781424491711
DOI	10.1109/RSETE.2011.5965885
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-06-24
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Proteins Osteoporosis Rats Fibroblasts Bones Mice Polygonatum sibiricum polysaccharide Bone protective Tumors
Content Type	Text
Resource Type	Article

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