NDLI: Lipid lowering activity of (E)-3-[4-[2-(4-chlorophenoxy)-2-methylpropanoylox y]-3-methoxyphenyl] acrylic acid (AZ) in hyperlipidemic rats

Content Provider	IEEE Xplore Digital Library
Author	Xiao-Bing Chen Jun Xu Po Zhao Zun-Hua Yang Hong Peng
Copyright Year	2011
Description	Author affiliation: Laboratory for Pharmacochemistry JiangXi University of Traditional Chinese Medicine, Nanchang 330009, China (Xiao-Bing Chen; Jun Xu; Po Zhao; Zun-Hua Yang; Hong Peng)
Abstract	Hyperlipidemia is closely related to Cardiovascular Disease, and also an important risk factor to affect Atherosclerosis, Coronary Heart Disease (CHD) and other Cardiovascular Disease. And hyperlipidemia could severely affect the health of human. In order to find better biological activity of lowering blood-lipids, we introduced the target compound of AZ. The lead compound were designed and synthesized by chlorophenoxy isobutyric acid of chemical lowering blood-lipid drugs and ferulic acid which is traditional Chinese medicine active products. The structure of the target compound prepared were confirmed by IR, MS, 1H-NMR, and elemental analysis. The herbicidal results show that the target compound has good lowering hyperlipidemia activities.
Starting Page	7664
Ending Page	7667
File Size	142514
Page Count	4
File Format	PDF
ISBN	9781424491728
e-ISBN	9781424491711
DOI	10.1109/RSETE.2011.5966150
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-06-24
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Drugs Biological activities Synthesis Biological system modeling Hyperlipidemia Atherosclerosis Rats Lipidomics Compounds Blood Esterification
Content Type	Text
Resource Type	Article

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