NDLI: Establishment of thromboangitis obliterans in rats

Content Provider	IEEE Xplore Digital Library
Author	Wei Wang Ying Liu Zhanqing Yang Wei Chen Chuanping Yuan Shoupeng Fu Juxiong Liu
Copyright Year	2011
Description	Author affiliation: Jilin university, College of Animal Science and Veterinary, Changchun, China (Wei Wang; Ying Liu; Zhanqing Yang; Wei Chen; Chuanping Yuan; Shoupeng Fu; Juxiong Liu)
Abstract	This project utilize surgery combine chemical method to establish rat model of thromboangitis obliterans. To appraise the model we use the method of pathology, immunology and molecular biology. The result shows that injection with laurate sodium to Femoral Artery can successfully establish rat model of thromboangitis obliterans that similar to human natural disease. Rat model pathological changes obviously, the expression of intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 mRNA rise significant in the disease region of rats, thromboxane B2 and anti-endothelial cell antibody increased significant in rats serum. These character was the same as thromboangitis obliterans in human. The rat model of thromboangitis obliterans can be used in further study, this offer a platform for the research of the pathologic mechanism and treatment of these disease.
Starting Page	6830
Ending Page	6834
File Size	1678248
Page Count	5
File Format	PDF
ISBN	9781424491728
e-ISBN	9781424491711
DOI	10.1109/RSETE.2011.5965932
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-06-24
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Animal model Adhesives RNA Biological system modeling DNA Cloning Rats Laurate sodium Thromboangitis obliterans Diseases
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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