NDLI: Modeling of drosophila circadian system based on locomotor activity

Content Provider	IEEE Xplore Digital Library
Author	Jiaxiang Zhang Wen, J.T. Julius, A.
Copyright Year	2011
Description	Author affiliation: Rensselaer Polytech. Inst., Troy, NY, USA (Jiaxiang Zhang; Wen, J.T.; Julius, A.)
Abstract	Due to the 24-hour lighting-dark cycle on earth, circadian rhythm regulates the biochemical and physiological processes of almost all living organisms, including plants, insects, and mammals. Maintaining the regular cyclicity of this internal clock, called entrainment, is important to the well being of an organism. For human, circadian disruption can lead to lower productivity, digestive problems, decreased sleep efficiency and other health problems. Various models have been proposed for the circadian rhythm, from empirical oscillator type models to genetic network based biochemical models. These models are used to gain insight into the mechanism governing the circadian rhythm, but may also be used to formulate light-based control strategies for its regulation. As a first step towards our eventual goal of light based circadian rhythm regulation for human, we are conducting experiments with drosophila (fruit fly), measuring the interaction between light intensity and wavelength and its locomotive activity level. Instead of the high order biochemical models proposed in the past, we consider a second order empirical oscillator model, with light intensity as input and activity as the output. By first entraining the flies in a regular rhythm and then observe the effect of light pulses, we are able to identify the model parameters based on the input/output experimental data. The model shows promising predictive capability: Our simulation shows that two blue pulses can shift the phase of drosophila circadian pacemaker by 12 hours, while the experiment result is 13.3 hours.
Sponsorship	Control Syst. Soc.
Starting Page	3496
Ending Page	3501
File Size	336009
Page Count	6
File Format	PDF
ISBN	9781457700804
ISSN	07431619
e-ISBN	9781457700811
DOI	10.1109/ACC.2011.5991447
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-06-29
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	American Automatic Control Council(AACC)
Subject Keyword	Pacemakers Biological system modeling Circadian rhythm Limit-cycles Oscillators Humans Temperature measurement
Content Type	Text
Resource Type	Article
Subject	Electrical and Electronic Engineering

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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