NDLI: Constrained dynamic control of focal trajectory and intensity of phased array ultrasound thermal therapies

Content Provider	IEEE Xplore Digital Library
Author	Ran Niu Skliar, M.
Copyright Year	2011
Description	Author affiliation: Univ. of Utah, Salt Lake City, UT, USA (Ran Niu; Skliar, M.)
Abstract	Long treatment times and normal tissue damage have been identified as major problems of ultrasound (US) surgery when large tumor volumes are treated, or when a tumor is located in close proximity to critical normal tissues. In this paper, a treatment control system that automatically selects location and intensity of the US focal zone to deliver the prescribed thermal dose to the target in minimum time without violating explicitly-imposed normal tissue safety constraints is developed. The controller is characterized by its time-optimal performance and direct incorporation of normal tissue constraints. To minimize the treatment time, which can be substantial with the explicit safety constraints, the control system applies the maximum US power for as long as possible without violating constraints by automatically changing focal zone locations to continue therapy at the maximum possible power. When there are no untreated locations where the maximum power can be applied without violating safety objectives, the control system selects focal locations and intensities such that the treatment is completed with at least one of the safety constraints active. The developed approach is evaluated in a computer-simulated treatment of a patient-specific three-dimensional breast tumor heated by an US phased array system.
Sponsorship	Control Syst. Soc.
Starting Page	5438
Ending Page	5443
File Size	502461
Page Count	6
File Format	PDF
ISBN	9781457700804
ISSN	07431619
e-ISBN	9781457700811
DOI	10.1109/ACC.2011.5991388
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-06-29
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	American Automatic Control Council(AACC)
Subject Keyword	Tumors Ultrasonic imaging Safety Control systems Arrays Transducers Medical treatment
Content Type	Text
Resource Type	Article
Subject	Electrical and Electronic Engineering

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