NDLI: Building a surface atlas of hippocampal subfields from MRI scans using FreeSurfer, FIRST and SPHARM

Content Provider	IEEE Xplore Digital Library
Author	Shan Cong Rizkalla, M. Du, E.Y. West, J. Risacher, S. Saykin, A. Li Shen
Copyright Year	2014
Description	Author affiliation: Dept. of Radiol. & Imaging Sci., Indiana Univ., Indianapolis, IN, USA (West, J.; Risacher, S.; Saykin, A.; Li Shen) \|\| Dept. of Electr. & Comput. Eng., Purdue Univ., Indianapolis, IN, USA (Shan Cong; Rizkalla, M.; Du, E.Y.)
Abstract	The hippocampus is widely studied with neuroimaging techniques given its importance in learning and memory and its potential as a biomarker for brain disorders such as Alzheimer's disease and epilepsy. However, its complex folding anatomy often presents analytical challenges. In particular, the critical hippocampal subfield information is usually ignored by hippocampal registration in detailed morphometric studies. Such an approach is thus inadequate to accurately characterize hippocampal morphometry and effectively identify hippocampal structural changes related to different conditions. To bridge this gap, we present our initial effort towards building a computational framework for subfield-guided hippocampal morphometry. This initial effort is focused on surface-based morphometry and aims to build a surface atlas of hippocampal subfields. Using the FreeSurfer software package, we obtain valuable hippocampal subfield information. Using the FIRST software package, we extract reliable hippocampal surface information. Using SPHARM, we develop an approach to create an atlas by mapping interpolated subfield information onto an average surface. The empirical result using ADNI data demonstrates the promise and good reproducibility of the proposed method.
Starting Page	813
Ending Page	816
File Size	2090438
Page Count	4
File Format	PDF
ISBN	9781479941346
ISSN	15483746
e-ISBN	9781479941322
DOI	10.1109/MWSCAS.2014.6908539
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-08-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Magnetic resonance imaging Hippocampus Surface treatment Shape Surface reconstruction Diseases Three-dimensional displays
Content Type	Text
Resource Type	Article
Subject	Electronic, Optical and Magnetic Materials Electrical and Electronic Engineering

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