NDLI: Fast Detection of Biological Targets With Magnetic Marker and SQUID

Content Provider	IEEE Xplore Digital Library
Author	Enpuku, K. Tokumitsu, H. Sugimoto, Y. Kuma, H. Hamasaki, N. Tsukamoto, A. Mizoguchi, T. Kandori, A. Yoshinaga, K. Kanzaki, H. Usuki, N.
Copyright Year	2002
Abstract	We have been developing a SQUID system for the detection of biological targets. In this system, magnetic markers are bound to the targets, and the magnetic signal from the bound markers is detected with the SQUID. In order to realize fast detection of the targets, we developed a liquid-phase detection method. First, we used large polymer beads as material to capture the targets. Since the polymer beads are uniformly dispersed in liquid, biological targets on the surface of the polymer bead can be easily coupled to the markers, which results in the fast reaction time. Next, we detected the bound markers without using the washing process to separate the bound and unbound markers, which was realized by using the difference in the Brownian relaxation time between them. Using this procedure, we demonstrated the detection of the target called IgE, as well as biotin-coated polymer beads. We obtained a good relationship between the amount of IgE and the magnetic signal. The result was the same as that obtained using the conventional procedure. The reaction time for the coupling between the magnetic marker and the target was 4 min, which was much shorter than the conventional method. These results show the usefulness of the present method.
Sponsorship	Council on Superconductivity Appl. Superconductivity Conference Inc MIT
Starting Page	844
Ending Page	847
Page Count	4
File Size	193679
File Format	PDF
ISSN	10518223
Volume Number	19
Issue Number	3
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-06-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	SQUIDs Magnetic separation Superconducting magnets Polymers Immune system Couplings Magnetic liquids Nanoparticles Chemistry Chemical technology magnetic marker BF separation Brownian rotation HTS SQUID immunoassay liquid-phase detection
Content Type	Text
Resource Type	Article
Subject	Condensed Matter Physics Electronic, Optical and Magnetic Materials Electrical and Electronic Engineering

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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