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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Guo, X. Q. Chen, R. Xu, C. S. Xue, D. M. Niu, Z. P. |
| Description | Country affiliation: China Author Affiliation: Xue DM ( College of Life Science, Henan Normal University, Xinxiang, Henan, China.); Guo XQ ( College of Life Science, Henan Normal University, Xinxiang, Henan, China.); Chen R ( College of Life Science, Henan Normal University, Xinxiang, Henan, China.); Niu ZP ( College of Life Science, Henan Normal University, Xinxiang, Henan, China.); Xu CS ( College of Life Science, Henan Normal University, Xinxiang, Henan, China cellkeylab@126.com.) |
| Abstract | 14-3-3 Proteins are a ubiquitous family of molecules that participate in protein kinase signaling pathways in all eukaryotic cells. Functioning as phosphoserine/phosphothreonine-binding modules, 14-3-3 proteins participate in the phosphorylation-dependent protein-protein interactions that control progression through the cell cycle, initiation and maintenance of DNA damage checkpoints, activation of MAP kinases, prevention of apoptosis, and coordination of integrin signaling and cytoskeletal dynamics. During liver regeneration after partial hepatectomy, normally quiescent hepatocytes undergo hypertrophy and proliferation to restore the liver mass. In this study, we investigated the expression patterns of 14-3-3 mRNAs in regenerating rat liver after 2/3 partial hepatectomy using real-time quantitative reverse transcription-polymerase chain reaction. All mRNAs of the 14-3-3 7 isotypes were expressed at 10 time points. Upregulation of 14-3-3x mRNA expression and downregulation of 14-3-3s mRNA expression from 0 to 6 h may play important roles in the entry into S-phase. Downregulation of 14-3-3b, g, s, h, and t mRNA expression from 24 to 30 h, when compared to 0 h, was closely related to entry into mitosis. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 1 |
| Volume Number | 14 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2015-03-20 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | 14-3-3 Proteins Genetics Hepatocytes Physiology Liver Regeneration Biosynthesis Animals Gene Expression Hepatectomy Cytology Metabolism Rna, Messenger Rats, Sprague-dawley Real-time Polymerase Chain Reaction Comparative Study Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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