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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lv, Y. W. Cui, X. H. Niu, J. H. Jiang, L. H. Hou, J. Zhang, M. Yang, L. |
| Description | Country affiliation: China Author Affiliation: Lv YW ( Department of Obstetrics and Gynecology, PLA 463rd Hospital, Shenyang, Liaoning Province, China yanwenlvcn@126.com.); Yang L ( Department of Obstetrics and Gynecology, PLA 463rd Hospital, Shenyang, Liaoning Province, China.); Zhang M ( Department of Obstetrics and Gynecology, PLA 463rd Hospital, Shenyang, Liaoning Province, China.); Jiang LH ( Department of Obstetrics and Gynecology, PLA 463rd Hospital, Shenyang, Liaoning Province, China.); Niu JH ( Department of Obstetrics and Gynecology, PLA 463rd Hospital, Shenyang, Liaoning Province, China.); Hou J ( Department of Obstetrics and Gynecology, PLA 463rd Hospital, Shenyang, Liaoning Province, China.); Cui XH ( Department of Obstetrics and Gynecology, PLA 463rd Hospital, Shenyang, Liaoning Province, China.) |
| Abstract | We examined the serum concentration of human epididymis protein (HE4) in patients with benign gynecological diseases complicated with chronic renal deficiency and its significance in the differential diagnosis of benign and malignant gynecological diseases. Serum HE4 and cancer antigen 125 concentrations were detected by chemiluminescence. Clinically or pathologically confirmed gynecological diseases were grouped and retrospectively analyzed, including 50 cases of gynecological benign diseases, 35 cases of non-mucinous epithelial ovarian carcinoma, 36 cases of endometrial adenocarcinoma, 15 cases of gynecological benign diseases patients complicated with chronic renal deficiency, 15 cases of gynecological diseases without chronic renal deficiency, and 30 normal controls. Serum HE4 values in the ovarian cancer group, endometrial cancer group, gynecological benign diseases with chronic renal deficiency group, and chronic renal deficiency group were significantly increased compared with the benign gynecological diseases and normal control groups, showing a significant difference (P < 0.001). A comparison of 4 groups with high HE4 showed that the HE4 level in the 2 groups with renal deficiency were higher than those in the ovarian cancer and endometrial cancer groups, but the difference was not significant (P > 0.05); there was no significant difference between 2 groups with renal deficiency (P > 0.05). Serum concentration of HE4 was high in patients with chronic renal deficiency, which should be distinguished during differential diagnosis of gynecological benign and malignant tumors in patients with chronic renal deficiency to avoid misdiagnosis. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 1 |
| Volume Number | 14 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2015-03-27 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Genital Diseases, Female Blood Proteins Metabolism Renal Insufficiency, Chronic Biological Markers Ca-125 Antigen Complications Diagnosis Ovarian Neoplasms Retrospective Studies Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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