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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lee, S. J. Kim, J. Kim, J. H. Jo, D. H. Hoang, M. H. Yu, Y. S. Lee, J. H. Wen, Q. Jun, H. J. |
| Description | Author Affiliation: Jo DH ( Fight Against Angiogenesis-Related Blindness Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.); Lee JH ( Division of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Institute of Biomedical Science and Safety, Korea University, Seoul, Republic of Korea.); Jun HJ ( Division of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Institute of Biomedical Science and Safety, Korea University, Seoul, Republic of Korea.); Kim J ( Fight Against Angiogenesis-Related Blindness Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.); Wen Q ( Division of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Institute of Biomedical Science and Safety, Korea University, Seoul, Republic of Korea.); Hoang MH ( Division of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Institute of Biomedical Science and Safety, Korea University, Seoul, Republic of Korea.); Yu YS ( Fight Against Angiogenesis-Related Blindness Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.); Kim JH ( Fight Against Angiogenesis-Related Blindness Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.); Lee SJ ( Division of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Institute of Biomedical Science and Safety, Korea University, Seoul, Republic of Korea junelee@korea.ac.kr.) |
| Abstract | Age-related macular degeneration (AMD) causes visual impairment in the elderly. In non-neovascular AMD, studies involving human subjects have suggested potential involvement of aberrant lipid metabolism. However, there have been no reports on gene expression patterns in animal models of non-neovascular AMD with abnormal lipid metabolism such as apolipoprotein E knockout and human apolipoprotein E2 transgenic mice. Transcriptome analysis was performed using retinal pigment epithelium cells of apoE knockout and apolipoprotein E2 mice using microarray analysis. C57BL/6, Rxrb, Pparbp, Vldlr, and Edf1, which are primarily related to lipid metabolism, were upregulated, while Tgfbr1 and Pdgfb, which are related to pathologic angiogenesis in AMD, were downregulated in both types of mice. Apolipoprotein E knockout and apolipoprotein E2 mice showed characteristic gene expression patterns in the transcriptome analysis of primary retinal pigment epithelium cells. These results suggest that specific genes associated with lipid metabolism and angiogenesis are involved in the pathogenesis and progression of AMD. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 1 |
| Volume Number | 14 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2015-03-13 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Apolipoprotein E2 Genetics Epithelial Cells Metabolism Retinal Pigment Epithelium Cytology Transcriptome Animals Apolipoproteins E Calmodulin-binding Proteins Dna-binding Proteins Disease Models, Animal Down-regulation Lipid Metabolism Lymphokines Macular Degeneration Mice Mice, Inbred C57bl Mice, Knockout Mice, Transgenic Microarray Analysis Ppar-beta Platelet-derived Growth Factor Protein-serine-threonine Kinases Receptors, Ldl Receptors, Transforming Growth Factor Beta Up-regulation Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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