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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ma, X. P. Yang, S. E. Fan, X. W. Guo, L. Hu, X. Liu, W. Li, Y. Liang, X. Li, X. |
| Description | Country affiliation: China Author Affiliation: Li X ( Department of Internal Medicine III, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi, China.); Fan XW ( Department of International Radiology, Affliliated Tumor Hospital, Xinjiang Medical University, Urumqi, China.); Liu W ( Department of Internal Medicine III, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi, China.); Guo L ( Department of Internal Medicine III, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi, China.); Li Y ( Department of Internal Medicine III, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi, China.); Hu X ( Department of Internal Medicine III, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi, China.); Liang X ( Department of Internal Medicine III, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi, China.); Ma XP ( Department of Internal Medicine III, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi, China.); Yang SE ( Department of Internal Medicine III, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi, China shuneyang@yeah.net.) |
| Abstract | The goal of this study was to investigate damaged liver function after chemotherapy in hepatitis B virus (HBV) carriers with non-Hodgkin lymphoma (NHL) and to evaluate risk factors associated with a high risk of damaged liver function. Clinical histories of 134 HBV carriers with NHL who were treated with chemotherapy were obtained and analyzed for the occurrence of damaged liver function and other related high-risk factors. Analysis showed that 76 patients (56.7%) had damaged liver function after chemotherapy: 6 patients (7.9%) had I degree, 17 patients (22.4%) had II degree, 20 patients (26.3%) had III degree, and 33 patients (43.4%) had IV degree damage. After treatment, 18 patients (23.7%) continued to receive chemotherapy according to their original schedule, 39 patients (51.3%) delayed chemotherapy, 16 patients (21.1%) stopped chemotherapy, and 3 patients (3.9%) died. Analysis of a binary multivariate logistic regression model showed that administration of steroids was a high-risk factor for damaged liver function after chemotherapy in NHL patients. The incidence of damaged liver function after chemotherapy is high among HBV carriers with NHL; therefore, administration of steroid chemotherapy is a high-risk factor. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 1 |
| Volume Number | 14 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2015-03-30 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Antineoplastic Combined Chemotherapy Protocols Therapeutic Use Hepatitis B Physiopathology Liver Lymphoma, Non-hodgkin Drug Therapy Adolescent Adverse Effects Drug-induced Liver Injury Diagnosis Etiology Virology Complications Hepatitis B Virus Physiology Host-pathogen Interactions Pathology Logistic Models Multivariate Analysis Outcome Assessment (health Care) Statistics & Numerical Data Retrospective Studies Risk Factors Severity Of Illness Index Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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