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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Xu, L. X. Fang, F. Wang, J. Li, G. Su, G. H. Pan, J. |
| Description | Country affiliation: China Author Affiliation: Fang F ( Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China baseff77@gmail.com.); Wang J ( Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China.); Pan J ( Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China.); Su GH ( Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China.); Xu LX ( Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China.); Li G ( Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China.) |
| Abstract | The vitamin D (1,25-dihydroxyvitamin D3) receptor (VDR) gene encodes a protein that functions in the transcriptional regulation of vitamin D-responsive genes and plays a role in innate immunity and adaptive immune responses. In this study, we investigated the relationship between VDR polymorphisms (BsmI, ApaI, and TaqI) and primary biliary cirrhosis (PBC) risk. We conducted an overall meta-analysis and subgroup meta-analysis based on ethnicity that included a total of 6 eligible studies (672 cases and 1148 controls). We detected no significant PBC risk variation for all genetic models in the overall analysis and in the subgroup analysis based on ethnicity for the BsmI polymorphism. For the ApaI polymorphism, significant associations were observed in the overall analysis as well as in the Asian subgroup. Furthermore, in the subgroup analysis based on ethnicity, a significant association was observed in the Caucasian subgroup but not in the Asian subgroup for the TaqI polymorphism. Based on the results of our meta-analysis, the VDR BsmI polymorphism may not be associated with PBC risk, while the VDR ApaI polymorphism is likely associated with PBC risk, particularly in Asians. The VDR TaqI polymorphism may be associated with PBC risk in Caucasians. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 1 |
| Volume Number | 14 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2015-02-06 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Genetic Association Studies Liver Cirrhosis, Biliary Genetics Receptors, Calcitriol Asian Continental Ancestry Group European Continental Ancestry Group Genetic Predisposition To Disease Genotype Pathology Polymorphism, Restriction Fragment Length Risk Factors Vitamin D Analogs & Derivatives Metabolism Meta-analysis Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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