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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pesarini, J. R. Ogo, F. M. Navarro, S. D. Oliveira, R. J. Mauro, M. O. |
| Description | Country affiliation: Brazil Author Affiliation: Navarro SD ( Centro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica-CeTroGen, Núcleo de Hospital Universitário, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil.); Mauro MO ( Centro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica-CeTroGen, Núcleo de Hospital Universitário, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil.); Pesarini JR ( Centro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica-CeTroGen, Núcleo de Hospital Universitário, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil.); Ogo FM ( Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, PR, Brasil.); Oliveira RJ ( Centro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica-CeTroGen, Núcleo de Hospital Universitário, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil rodrigo.oliveira@ufms.br.) |
| Abstract | Resistant starch is formed from starch and its degradation products and is not digested or absorbed in the intestine; thus, it is characterized as a fiber. Because fiber intake is associated with the prevention of DNA damage and cancer, the potential antigenotoxic, antimutagenic, and anticarcinogenic capabilities of resistant starch from green banana flour were evaluated. Animals were treated with 1,2-dimethylhydrazine and their diet was supplemented with 10% green banana flour according to the following resistant starch protocols: pretreatment, simultaneous treatment, post-treatment, and pre + continuous treatment. The results demonstrated that resistant starch is not genotoxic, mutagenic, or carcinogenic. The results suggest that resistant starch acts through desmutagenesis and bio-antimutagenesis, as well as by reducing aberrant crypt foci, thereby improving disease prognosis. These findings imply that green banana flour has therapeutic properties that should be explored for human dietary applications. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 1 |
| Volume Number | 14 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2015-03-06 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Carcinogenesis Drug Effects Dna Damage Dietary Fiber Administration & Dosage Functional Food Starch Chemistry Aberrant Crypt Foci Animals Colorectal Neoplasms Prevention & Control Comet Assay Dimethylhydrazines Adverse Effects Disease Models, Animal Flour Food Handling Mice Micronucleus Tests Musa Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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