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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chai, Ya-Qin Zhuo, Ying Zhou, Ying Yuan, Ruo Wang, Jing-Xi |
| Description | Author Affiliation: Wang JX ( Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.); Zhuo Y ( Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.); Zhou Y ( Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.); Yuan R ( Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China. Electronic address: yuanruo@swu.edu.cn.); Chai YQ ( Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China. Electronic address: yqchai@swu.edu.cn.) |
| Abstract | In this work, a novel and multifunctional nanocomposite of luminol capped gold modified Fe3O4 (Lu-AuNPs@Fe3O4) was utilized as the carrier of secondary antibody (Ab2) to fabricate a sandwiched electrochemiluminescence (ECL) immunosensor for ultrasensitive detection of mucin-1 (MUC1). Herein, the luminol capped gold nanoparticles (Lu-AuNPs) were synthesized with HAuCl4 and luminol by the help of NaBH4 at room temperature, and then Lu-AuNPs were adsorbed on the Fe3O4 magnetic nanoparticles (MNPs) to form the nanocomposite of Lu-AuNPs@Fe3O4 via electrostatic interaction. Fe3O4 MNPs in Lu-AuNPs@Fe3O4 exhibited excellent conductivity and admirable catalytic activity in H2O2 decomposition, which could enhance the ECL efficiency of luminol-H2O2 system. In addition, the substrates of gold coated ZnO nanoparticles (AuNPs@ZnO), providing large specific surface areas for primary antibody (Ab1) capturing, were modified on the electrode. As a result, a wide linear range of 7 orders of magnitude from 10 fg/mL to 10 ng/mL was obtained with an ultralow detection limit of 4.5 fg/mL for MUC1. |
| ISSN | 09565663 |
| Volume Number | 71 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-09-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Conductometry Instrumentation Immunoassay Luminescent Measurements Luminol Chemistry Magnetite Nanoparticles Nanocomposites Equipment Design Equipment Failure Analysis Gold Metal Nanoparticles Mucin-1 Immunology Ultrastructure Reproducibility Of Results Sensitivity And Specificity Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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