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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jen, Nelson Tai, Yuchong Lee, Chia-An Hsiai, Tzung K. Beebe, Tyler Zhang, Xiaoxiao |
| Description | Country affiliation: United States Author Affiliation: Zhang X ( Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, USA.); Beebe T ( Department of Bioengineering, UCLA School of Engineering & Applied Sciences, Los Angeles, CA 90095, USA.); Jen N ( Department of Bioengineering, UCLA School of Engineering & Applied Sciences, Los Angeles, CA 90095, USA.); Lee CA ( Division of Cardiology, Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095, USA.); Tai Y ( Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, USA.); Hsiai TK ( Department of Bioengineering, UCLA School of Engineering & Applied Sciences, Los Angeles, CA 90095, USA) |
| Abstract | Flexible electronics are the next generation of sensors for mobile health and implantation. Zebrafish (Danio rerio) is an emergent strategy for pre-clinical drug development and toxicity testing. To address the confounding effects from sedation of fish and removal from the aquatic habitat for micro-electrocardiogram (µECG) measurements, we developed waterproof and wearable sensors to uncover the circadian variation in heart rate (HR) and heart rate variability (HRV) (Massin et al., 2000). The parylene-C based ECG sensor consisted of an ultra-soft silicone integrated jacket designed to wrap around the fish during swimming. The Young's modulus of this silicone jacket matched with the fish surface, and an extended parylene cable connected the underwater chest electrodes with the out-of water electronics. In addition, embedded micro-glass spheres in the silicone effectively reduced the effective density of the jacket to ~1 g cm(-3). These innovations enabled physiological ECG telemetry in the fish's natural habitat without the need for sedation. Furthermore, a set of non-linear signal processing techniques filtered out the breathing and electromagnetic artifacts from the recorded signals. We observed a reduction in mean HR and an increase in HRV over 24h at 10 dpa, accompanied by QT prolongation as well as diurnal variations, followed by normalization in mean HR and QT intervals at 26 days post ventricular amputation (dpa). We revealed Amiodarone-mediated QTc prolongation, HR reduction and HRV increase otherwise masked by sedation. The novel features of the flexible silicon jacket for µECG telemetry unraveled the biological clock and normalization of QT intervals at 26 dpa, providing the first evidence of new physiological phenomena during cardiac injury and repair as well as cardiac drug-mediated aberrant rhythms. Thus, the light weight and waterproof design holds promise to advance the next generation of mobile health and drug discovery. |
| ISSN | 09565663 |
| e-ISSN | 18734235 |
| DOI | 10.1016/j.bios.2015.04.027 |
| Journal | Biosensors and Bioelectronics |
| Volume Number | 71 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-09-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Amiodarone Therapeutic Use Anti-arrhythmia Agents Biosensing Techniques Instrumentation Circadian Rhythm Drug Evaluation, Preclinical Electrocardiography Heart Ventricles Injuries Animals Arrhythmias, Cardiac Brugada Syndrome Electrodes Equipment Design Heart Conduction System Abnormalities Heart Rate Drug Effects Physiopathology Telemetry Zebrafish Research Support, N.i.h., Extramural Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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