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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Baghayeri, Mehdi Nazarzadeh Zare, Ehsan Mansour Lakouraj, Moslem |
| Description | Author Affiliation: Baghayeri M ( Department of Chemistry, Faculty of Science, Hakim Sabzevari University, P.O. Box 397, Sabzevar, Iran. Electronic address: m.baghayeri@hsu.ac.ir.); Nazarzadeh Zare E ( Department of Organic-Polymer Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran.); Mansour Lakouraj M ( Department of Organic-Polymer Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran.) |
| Abstract | The novel biocompatible poly(p-phenylenediamine) (PpPDA)-Fe3O4 nanocomposite (PpPDA@Fe3O4) was synthesized via emulsion polymerization. The PpPDA@Fe3O4 nanocomposite was characterized by Fourier transform infrared spectra (FT-IR), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM) and vibrating sample magnetometer (VSM). The PpPDA@Fe3O4 nanocomposite was then used as substrate for the immobilization of hemoglobin (Hb) and their bioelectrochemical behaviors were studied. Electrochemical impedance spectroscopy was used to confirm the adsorption of Hb onto the surface of PpPDA@Fe3O4 nanocomposite. The Hb immobilized on PpPDA@Fe3O4 nanocomposite retained its near-native conformations as characterized by the FT-IR. A pair of well-defined redox peaks of Hb was obtained at the Hb-PpPDA@Fe3O4 modified glassy carbon electrode (Hb-PpPDA@Fe3O4/GCE) through direct electron transfer between the protein and the underlying electrode. The proposed biosensor showed good reproducibility and high sensitivity to H2O2 with the detection limit of 0.21 µM (S/N=3). In the range of 0.5-400.0 µM, the catalytic reduction current of H2O2 was proportional to its concentration. The apparent Michaelis-Menten constant of Hb on the PpPDA@Fe3O4 nanocomposite was estimated to be 0.088 mM, showing its high affinity. |
| ISSN | 09565663 |
| Volume Number | 55 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-05-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Biosensing Techniques Instrumentation Electrodes Hydrogen Peroxide Analysis Magnetite Nanoparticles Chemistry Micro-electrical-mechanical Systems Nanocomposites Phenylenediamines Conductometry Electromagnetic Fields Equipment Design Equipment Failure Analysis Ultrastructure Reproducibility Of Results Sensitivity And Specificity Journal Article Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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