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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hu, Jianming Liu, Qian Tian, Jingqi Sun, Xuping Shi, Jinle He, Yuquan Asiri, Abdullah M. |
| Description | Country affiliation: China Author Affiliation: Tian J ( State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, China); Liu Q ( State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, China.); Shi J ( State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, China); Hu J ( Optical Engineering Key Laboratory of Chongqing Municipal Education Commission, College of Physics and Information Technology, Chongqing Normal University, Chongqing 40047, China.); Asiri AM ( Chemistry Department and Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia.); Sun X ( State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, China. Electronic address: sunxp@ciac.ac.cn.); He Y ( Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun 130033, China. Electronic address: yuquanhe@hotmail.com.) |
| Abstract | Considerable recent attention has been paid to homogeneous fluorescent DNA detection with the use of nanostructures as a universal 'quencher', but it still remains a great challenge to develop such nanosensor with the benefits of low cost, high speed, sensitivity, and selectivity. In this work, we report the use of iron-based metal-organic framework nanorods as a high-efficient sensing platform for fluorescent DNA detection. It only takes about 4 min to complete the whole 'mix-and-detect' process with a low detection limit of 10 pM and a strong discrimination of single point mutation. Control experiments reveal the remarkable sensing behavior is a consequence of the synergies of the metal center and organic linker. This work elucidates how composition control of nanostructures can significantly impact their sensing properties, enabling new opportunities for the rational design of functional materials for analytical applications. |
| ISSN | 09565663 |
| Volume Number | 71 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-09-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Dna Analysis Fluorescent Dyes Chemistry Iron Organometallic Compounds Biosensing Techniques Nanotubes Ultrastructure Spectrometry, Fluorescence Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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