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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tong, Feifei Lian, Yan He, Fengjiao |
| Description | Country affiliation: China Author Affiliation: Tong F ( State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.); Lian Y ( State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.); He F ( State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China. Electronic address: fengjiao87799232@hotmail.com.) |
| Abstract | A novel square Au microelectrode multi-channel series piezoelectric quartz crystal (S-MSPQC) cell sensor was constructed by square Au microelectrode in series connected with quartz crystal sensor in MSPQC. The experimental results showed square shape Au microelectrode was more sensitive than normally used interdigital microelectrode. New constructed S-MSPQC was successfully used for real time monitoring the injury of human umbilical vein endothelial cells which induced by lipopolysaccharide (LPS) and assessing the drug effects of two anti-oxidative vitamins, VC and VE and their combination against this injury. The detection results showed that the low concentration of LPS may promote the proliferation of the HUVEC cells at first 12h, then it caused the cell apoptosis. The pretreatment of VC or VE on the cells for 12h before adding the LPS could partially reduced the injury of LPS on HUVEC cells. The sensor detection results were all consisted with the results detected by MTT assay and microscopy observation. The synergistic effect of the combination of VC-VE on LPS-induced cell injury was also observed by sensor. Compared with the traditional biological methods, the proposed method is sensitive, label-free, non-invasive, cheap, simple, and automatic. It provides a new automatic tool for cell monitor in the field of cell biology, cytobiology, and drug effects research. |
| ISSN | 09565663 |
| Volume Number | 71 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-09-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Antioxidants Pharmacology Apoptosis Drug Effects Drug Evaluation, Preclinical Instrumentation Endothelial Cells Microbiology Escherichia Coli Immunology Lipopolysaccharides Ascorbic Acid Biosensing Techniques Electric Capacitance Electrochemical Techniques Cytology Pathology Equipment Design Human Umbilical Vein Endothelial Cells Humans Vitamin E Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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