NDLI: Preparation, characterization and in vitro dissolution behavior of porous biphasic /ß-tricalcium phosphate bioceramics.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Xie, Lu Yu, Haiyang Deng, Yi Yang, Weizhong Liao, Li Long, Qin
Description	Country affiliation: China Author Affiliation: Xie L ( State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu 610065, China.); Yu H ( State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu 610065, China. Electronic address: yhyang6812@scu.edu.cn.); Deng Y ( School of Chemical Engineering, Sichuan University, Chengdu 610065, China); Yang W ( School of Chemical Engineering, Sichuan University, Chengdu 610065, China.); Liao L ( School of Chemical Engineering, Sichuan University, Chengdu 610065, China.); Long Q ( School of Chemical Engineering, Sichuan University, Chengdu 610065, China.)
Abstract	The ideal bone tissue engineering scaffolds are long-cherished with the properties of interconnected macroporous structures, adjustable degradation and excellent biocompatibility. Here, a series of porous /ß-tricalcium phosphate ( /ß-TCP) biphasic bioceramics with different phase ratios of -TCP and ß-TCP were successfully synthesized by heating an amorphous calcium phosphate precursor. The chemical and morphological characterization showed that - and ß-TCP phases co-existed in the /ß-TCP bioceramics and they had interconnected pore structures with size between 200 and 500µm. The in vitro dissolution behavior and bioactivity of the dual /ß-TCP were also probed in static and dynamic SBF for the first time. The results revealed that /ß-TCP scaffolds had good in vitro bioactivity, as the formation of bone-like apatite layers was induced on the scaffolds after mineralization in SBF. Moreover, dissolution rate of /ß-TCP bioceramics in dynamic environment was higher than that under static condition. Compared with monophasic TCP ceramics, these porous /ß-TCP bioceramics displayed a tailored dissolution rate proportionate to the TCP content ( and ß) in the materials. Further, the degradation profile of porous /ß-TCP was well-described by Avrami equation. The porous dual /ß-TCP bioceramics with controllable degradation behavior hold great potential to be applied in bone tissue engineering as bone substitutes.
File Format	HTM / HTML
ISSN	09284931
Journal	Materials Science and Engineering: C
Volume Number	59
e-ISSN	18730191
Language	English
Publisher	Elsevier
Publisher Date	2016-02-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Materials Science Bone Substitutes Chemistry Calcium Phosphates Ceramics Tissue Scaffolds Tissue Engineering Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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