NDLI: Construction of novel sensitive electrochemical sensor for electro-oxidation and determination of citalopram based on zinc oxide nanoparticles and multi-walled carbon nanotubes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ghaedi, Hamed Afkhami, Abbas Madrakian, Tayyebeh Soltani-Felehgari, Farzaneh
Description	Author Affiliation: Ghaedi H ( Faculty of Engineering, Bushehr Branch, Islamic Azad University, Bushehr, Iran. Electronic address: hamedghaedi@gmail.com.); Afkhami A ( Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran.); Madrakian T ( Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran.); Soltani-Felehgari F ( Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran.)
Abstract	A new chemically modified carbon paste electrode (CMCPE) was applied to the simple, rapid, highly selective and sensitive determination of citalopram in human serum and pharmaceutical preparations using adsorptive square wave voltammetry (ASWV). The ZnO nanoparticles and multi-walled carbon nanotubes modified CPE (ZnO-MWCNT/CPE) electrode was prepared by incorporation of the ZnO nanoparticles and multi-walled carbon nanotubes (MWCNT) in carbon paste electrode. The limit of detection and the linear range were found to be 0.005 and 0.012 to 1.54µmolL(-1) of citalopram, respectively. The effects of potentially interfering substances on the determination of this compound were investigated and found that the electrode is highly selective. The proposed CMCPE was used to the determination of citalopram in human serum, urine and pharmaceutical samples. This reveals that ZnO-MWCNT/CPE shows excellent analytical performance for the determination of citalopram in terms of very low detection limit, high sensitivity, very good repeatability and reproducibility over other methods reported in the literature.
File Format	HTM / HTML
ISSN	09284931
Volume Number	59
e-ISSN	18730191
Journal	Materials Science and Engineering: C
Language	English
Publisher	Elsevier
Publisher Date	2016-02-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Materials Science Citalopram Analysis Electrochemical Techniques Methods Nanotubes, Carbon Chemistry Zinc Oxide Humans Sensitivity And Specificity Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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