NDLI: Mesoporous silica sub-micron spheres as drug dissolution enhancers: Influence of drug and matrix chemistry on functionality and stability.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Brigo, Laura Scomparin, Elisa Galuppo, Marco Capurso, Giovanni Ferlin, Maria Grazia Bello, Valentina Realdon, Nicola Brusatin, Giovanna Morpurgo, Margherita
Description	Country affiliation: Italy Author Affiliation: Brigo L ( Department of Industrial Engineering and INSTM Padova RU, University of Padova, via Marzolo 9, 35131 Padova, Italy); Scomparin E ( Department of Pharmaceutical and Pharmacological Sciences, University of Padova, via Marzolo 5, 35131, Padova, Italy.); Galuppo M ( Department of Pharmaceutical and Pharmacological Sciences, University of Padova, via Marzolo 5, 35131, Padova, Italy.); Capurso G ( Helmholtz-Zentrum Geesthacht, Institute of Materials Research - Dept. of Nanotechnology, Max-Planck-Strasse 1, D-21502 Geesthacht, Germany.); Ferlin MG ( Department of Pharmaceutical and Pharmacological Sciences, University of Padova, via Marzolo 5, 35131, Padova, Italy.); Bello V ( Department of Physics and Astronomy Galileo Galilei, University of Padova, via Marzolo 8, 35131 Padova, Italy.); Realdon N ( Department of Pharmaceutical and Pharmacological Sciences, University of Padova, via Marzolo 5, 35131, Padova, Italy.); Brusatin G ( Department of Industrial Engineering and INSTM Padova RU, University of Padova, via Marzolo 9, 35131 Padova, Italy.); Morpurgo M ( Department of Pharmaceutical and Pharmacological Sciences, University of Padova, via Marzolo 5, 35131, Padova, Italy. Electronic address: margherita.morpurgo@unipd.it.)
Abstract	Mesoporous silica particles prepared through a simplified Stöber method and low temperature solvent promoted surfactant removal are evaluated as dissolution enhancers for poorly soluble compounds, using a powerful anticancer agent belonging to pyrroloquinolinones as a model for anticancer oral therapy, and anti-inflammatory ibuprofen as a reference compound. Mesoporous powders composed of either pure silica or silica modified with aminopropyl residues are produced. The influence of material composition and drug chemical properties on drug loading capability and dissolution enhancement are studied. The two types of particles display similar size, surface area, porosity, erodibility, drug loading capability and stability. An up to 50% w/w drug loading is reached, showing correlation between drug concentration in adsorption medium and content in the final powder. Upon immersion in simulating body fluids, immediate drug dissolution occurred, allowing acceptor solutions to reach concentrations equal to or greater than drug saturation limits. The matrix composition influenced drug solution maximal concentration, complementing the dissolution enhancement generated by a mesoporous structure. This effect was found to depend on both matrix and drug chemical properties allowing us to hypothesise general prediction behaviour rules.
File Format	HTM / HTML
ISSN	09284931
Volume Number	59
e-ISSN	18730191
Journal	Materials Science and Engineering: C
Language	English
Publisher	Elsevier
Publisher Date	2016-02-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Materials Science Antineoplastic Agents Chemistry Drug Carriers Microspheres Nanoparticles Silicon Dioxide Drug Stability Phase Transition Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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