NDLI: Impact of pore characteristics of silica materials on loading capacity and release behavior of ibuprofen.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Numpilai, Thanapha Muenmee, Suthaporn Witoon, Thongthai
Description	Country affiliation: Thailand Author Affiliation: Numpilai T ( Department of Chemical Engineering, Faculty of Engineering, Kasetsart University, Bangkok 10900, Thailand.); Muenmee S ( Department of Chemical Engineering, Faculty of Engineering, Kasetsart University, Bangkok 10900, Thailand); Witoon T ( Department of Chemical Engineering, Faculty of Engineering, Kasetsart University, Bangkok 10900, Thailand)
Abstract	Impact of pore characteristics of porous silica supports on loading capacity and release behavior of ibuprofen was investigated. The porous silica materials and ibuprofen-loaded porous silica materials were thoroughly characterized by N2-sorption, thermal gravimetric and derivative weight analyses (TG-DTW), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), transmission electron microscope (TEM) to determine the physical properties of materials, amount of ibuprofen adsorbed and position of ibuprofen. The detailed characterization reveals that the ibuprofen molecules adsorbed inside the mesopores. Increasing the mesopore size from 5nm to 10nm increased the ibuprofen loading from 0.74 to 0.85mmol/g, respectively. Incorporation of macropore into the structure of porous silica materials enhanced the ibuprofen loading capacity of 11.8-20.3%. The ibuprofen-loaded bimodal meso-macroporous silica materials exhibited the highest dissolution of 92wt.% within an hour. The ibuprofen particles deposited on the external surface of the porous silica materials showed a lower dissolution rate than the ibuprofen adsorbed inside the mesopores due to the formation of ibuprofen crystalline.
File Format	HTM / HTML
ISSN	09284931
Journal	Materials Science and Engineering: C
Volume Number	59
e-ISSN	18730191
Language	English
Publisher	Elsevier
Publisher Date	2016-02-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Materials Science Ibuprofen Silicon Dioxide Chemistry Delayed-action Preparations Pharmacokinetics Porosity Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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