NDLI: In vitro evaluation of anti-calcification and anti-coagulation on sulfonated chitosan and carrageenan surfaces.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Campelo, Clayton Souza Lima, Luana Dias Rebêlo, Luciana Magalhães Mantovani, Diego Beppu, Marisa Masumi Vieira, Rodrigo Silveira
Description	Country affiliation: Brazil Author Affiliation: Campelo CS ( Chemical Engineering Department, Universidade Federal do Ceará, CEP 60455-760 Fortaleza, CE, Brazil.); Lima LD ( Chemical Engineering Department, Universidade Federal do Ceará, CEP 60455-760 Fortaleza, CE, Brazil.); Rebêlo LM ( Physics Department, Universidade Federal do Ceará, CEP 60455-900 Fortaleza, CE, Brazil.); Mantovani D ( Department of Min-Met-Materials Engineering, Laval University & University Hospital Research Center, G1V 0A6 Quebec City, QC, Canada.); Beppu MM ( Chemical Engineering Faculty, Universidade Estadual de Campinas, Caixa Postal 6066, CEP 13081-970 Campinas, SP, Brazil.); Vieira RS ( Chemical Engineering Department, Universidade Federal do Ceará, CEP 60455-760 Fortaleza, CE, Brazil.)
Abstract	In recent years, great effort has been devoted to the development of biomaterials that come into contact with blood. The surfaces of these materials need to be of suitable mechanical strength, and present anti-thrombogenic and anti-calcification properties. Chitosan is a natural polymer that has attracted attention due to its potential to act as a biomaterial. However, chitosan contains amino groups in its structure that may promote thrombogenesis and calcification. A strategy to reduce these properties constitutes the introduction of sulfonate groups (R-SO3-) in the chitosan chain. Another interesting biopolymer with similar characteristics to those of heparin is carrageenan, which has sulfate groups in its structure. As such, we evaluated 'in vitro' calcification and thrombogenic processes on surfaces of pristine and sulfonated chitosan and on polyelectrolyte complexes (PEC) of chitosan and carrageenan. Results indicate that PEC demonstrate significant reductions in calcification and thrombogenic potential, probably due to the presence of sulfonate groups in both the carrageenan and treated chitosan.
File Format	HTM / HTML
ISSN	09284931
Volume Number	59
e-ISSN	18730191
Journal	Materials Science and Engineering: C
Language	English
Publisher	Elsevier
Publisher Date	2016-02-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Materials Science Anticoagulants Blood Platelets Metabolism Carrageenan Chitosan Chemistry Pharmacology Drug Evaluation, Preclinical Female Humans Male Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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