NDLI: Porous calcium phosphate-poly (lactic-co-glycolic) acid composite bone cement: A viable tunable drug delivery system.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Roy, Abhijit Jhunjhunwala, Siddharth Bayer, Emily Fedorchak, Morgan Little, Steve R. Kumta, Prashant N.
Description	Country affiliation: United States Author Affiliation: Roy A ( Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, USA.); Jhunjhunwala S ( Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, USA.); Bayer E ( Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, USA.); Fedorchak M ( Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA 15261, USA.); Little SR ( Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, USA); Kumta PN ( Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, USA)
Abstract	Calcium phosphate based cements (CPCs) are frequently used as bone void fillers for non-load bearing segmental bone defects due to their clinically relevant handling characteristics and ability to promote natural bone growth. Macroporous CPC scaffolds with interconnected pores are preferred for their ability to degrade faster and enable accelerated bone regeneration. Herein, a composite CPC scaffold is developed using newly developed resorbable calcium phosphate cement (ReCaPP) formulation containing degradable microspheres of bio-compatible poly (lactic-co-glycolic acid) (PLGA) serving as porogen. The present study is aimed at characterizing the effect of in-vitro degradation of PLGA microspheres on the physical, chemical and structural characteristics of the composite cements. The porosity measurements results reveal the formation of highly interconnected macroporous scaffolds after degradation of PLGA microspheres. The in-vitro characterizations also suggest that the degradation by products of PLGA reduces the pH of the local environment thereby increasing the dissolution rate of the cement. In addition, the in-vitro vancomycin release from the composite CPC scaffold suggests that the drug association with the composite scaffolds can be tuned to achieve control release kinetics. Further, the study demonstrates control release lasting for longer than 10weeks from the composite cements in which vancomycin is encapsulated in PLGA microspheres.
File Format	HTM / HTML
ISSN	09284931
Volume Number	59
e-ISSN	18730191
Journal	Materials Science and Engineering: C
Language	English
Publisher	Elsevier
Publisher Date	2016-02-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Materials Science Bone Cements Calcium Phosphates Drug Delivery Systems Methods Lactic Acid Polyglycolic Acid Vancomycin Chemistry Pharmacokinetics Pharmacology Porosity Journal Article Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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