NDLI: Effect of PEGylated superparamagnetic iron oxide nanoparticles (SPIONs) under magnetic field on amyloid beta fibrillation process.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mirsadeghi, Somayeh Shanehsazzadeh, Saeed Atyabi, Fatemeh Dinarvand, Rassoul
Description	Country affiliation: Iran Author Affiliation: Mirsadeghi S ( Nanotechnology Research Center, School of Pharmacy, Tehran University of Medical Science, Tehran 1417614411, Iran.); Shanehsazzadeh S ( Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran.); Atyabi F ( Nanotechnology Research Center, School of Pharmacy, Tehran University of Medical Science, Tehran 1417614411, Iran); Dinarvand R ( Nanotechnology Research Center, School of Pharmacy, Tehran University of Medical Science, Tehran 1417614411, Iran)
Abstract	Superparamagnetic iron oxide nanoparticles (SPIONs) with specific surface coatings have been shown appropriate potential in the diagnosis and treatment of various brain diseases such as Alzheimer's. Comprehensive understanding of SPIONs interactions with amyloid beta (Aß) and other amyloidogenic proteins is essential for their clinical application. SPIONs could be delivered to the target tissue under the magnetic field, while they might be influenced by the applied field. In this work, we exhibit the effect of different SPIONs (magnetized or non-magnetized with different surface charges) on the kinetics of Aß fibrillation in aqueous solution by the aid of ThT assay. The results showed that applying of magnetic field to the SPIONs influences on the Aß fibrillation because of its effect on the size due to surface charge. It was found that under magnetic field and high concentrations of nanoparticles (SPIONs-PEG-NH2), the Aß fibrillation process accelerates, while at lower concentrations the fibrillation is inhibited. Furthermore, the coating charge has a considerable role in fibrillation process and the positively charged SPIONs/magnetized, at lower particle concentrations, accelerate the fibrillation compared with the negatively charged or uncharged SPIONs. This hints that SPIONs with a positive charge have dual effects on the Aß fibrillation process. They influence on the concentration of monomeric protein in solution and thereby the nucleation time. Also, SPIONs have an effect on binding during the protein conformation.
File Format	HTM / HTML
ISSN	09284931
Journal	Materials Science and Engineering: C
Volume Number	59
e-ISSN	18730191
Language	English
Publisher	Elsevier
Publisher Date	2016-02-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Materials Science Amyloid Beta-peptides Chemistry Magnetic Fields Magnetite Nanoparticles Polyethylene Glycols Humans Journal Article
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Biomaterials Condensed Matter Physics Bioengineering Mechanical Engineering

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